Role of micronutrients in Alzheimer's disease: Review of available evidence.
Role of micronutrients in Alzheimer's disease: Review of available evidence.
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DOI：
10.12998/wjcc.v10.i22.7631
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发表时间：
2022-08-06
影响因子：
1.1
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中科院分区：
文献类型：
--
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阿尔茨海默病（Alzheimer's disease，AD）是最常见的与年龄相关的神经退行性疾病之一，已有100多年的研究历史。虽然淀粉样前体蛋白水平的增加被认为是AD发展的关键因素，但确切的致病机制仍然是已知的。多种因素与AD相关，如遗传因素、衰老、生活方式和营养。流行病学和临床证据均表明，微量营养素（如铜、锌和铁）的水平与AD的发生密切相关。本文根据近年来的研究成果，对铜、锌、铁、硒、硅、锰、砷和维生素D等8种微量营养素在AD中的作用进行综述。
Alzheimer's disease (AD) is one of the most common age-related neurodegenerative disorders that have been studied for more than 100 years. Although an increased level of amyloid precursor protein is considered a key contributor to the development of AD, the exact pathogenic mechanism remains known. Multiple factors are related to AD, such as genetic factors, aging, lifestyle, and nutrients. Both epidemiological and clinical evidence has shown that the levels of micronutrients, such as copper, zinc, and iron, are closely related to the development of AD. In this review, we summarize the roles of eight micronutrients, including copper, zinc, iron, selenium, silicon, manganese, arsenic, and vitamin D in AD based on recently published studies.
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