TAS2R38 polymorphisms, Helicobacter pylori infection and susceptibility to gastric cancer and premalignant gastric lesions.
TAS2R38 polymorphisms, Helicobacter pylori infection and susceptibility to gastric cancer and premalignant gastric lesions.
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DOI：
10.1097/cej.0000000000000722
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发表时间：
2022-09-01
期刊：
影响因子：
--
通讯作者：
Campa D
中科院分区：
文献类型：
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作者：
Giaccherini M;Rizzato C;Gentiluomo M;Lupetti A;Flores-Luna L;Vivas J;Bravo MM;Kasamatsu E;Muñoz N;Canzian F;Kato I;Campa D
胃癌是世界上发病率第四大的常见癌症，死亡率第三大。我们分析了TAS2R38基因的三个错义变体：rs713598 （A49P）、rs1726866 （V262A）和rs10246939 （I296V）。这些变异及其在单倍型（PAV/味觉者或AVI/非味觉者）和双倍型中的组合导致了个体对苦味感知的差异。已知单核苷酸多态性和相关表型与革兰氏阴性细菌感染（如幽门螺杆菌）的易感性相关，并与各种癌症类型的风险相关。据报道，在韩国人群中，中级味觉者（由TAS2R38双倍型定义）与胃癌风险增加之间存在关联。我们分析了拉丁美洲血统的2616个个体，代表了从胃炎到胃癌的整个病变谱。比较癌症病例与非癌症病例，我们观察到与更常见的等位基因纯合子相比，rs10246939和rs1726866杂合子携带者的风险降低（p=0.006）。此外，对双倍型/表型的分析也反映了相同的关联，与中等品酒者相比，超级品酒者患胃癌的风险增加（OR=1.63, 95%CI 1.04-2.56, p=0.033）。此外，与中等品尝者相比，非品尝者的风险增加，但没有达到统计学意义（OR=1.58, 95%CI 0.80-2.87, p=0.203）。我们还在一部分样本中测试了TAS2R38基因型与幽门螺杆菌cagA状态之间的相互作用，未发现相互作用。总之，我们的研究结果表明，TAS2R38基因的遗传变异在胃癌病因学中只有适度的贡献。
Gastric cancer is worldwide the fourth more common cancer type by incidence, and the third by mortality. We analyzed three missense variants of TAS2R38 gene: rs713598 (A49P), rs1726866 (V262A), and rs10246939 (I296V). These variants and their combination in haplotypes (PAV/tasters or AVI/non-tasters) and diplotypes are responsible for individual differences in bitter perception. The single nucleotide polymorphisms and the related phenotypes are known to be associated with susceptibility to Gram-negative bacterial infections, such as Helicobacter pylori, and with risk of various cancer types. An association between intermediate tasters (as defined by TAS2R38 diplotypes) and increased risk of gastric cancer was reported in a Korean population. we analyzed 2616 individuals of Latin American origin, representing the whole spectrum of lesions from gastritis to gastric cancer. Comparing cancer cases vs non-cancers we observed a decrease in risk associated with heterozygous carriers of rs10246939 (p=0.006) and rs1726866 (p=0.003) when compared with homozygotes of the more common allele. Also, the analysis of diplotypes/phenotypes reflected the same association, with super-tasters showing a borderline increased risk of developing gastric cancer compared to medium-tasters (OR=1.63, 95%CI 1.04-2.56, p=0.033). Also, non-tasters showed an increased risk when compared to medium-tasters although not reaching statistical significance (OR=1.58, 95%CI 0.80-2.87, p=0.203). We also tested the interactions between the TAS2R38 genotypes and H. pylori cagA status in a subset of samples and found no interaction. In conclusion, our results suggest only a modest contribution of TAS2R38 gene genetic variability in gastric cancer etiology.
影响因子：
3.7
作者：
Rizzato C;Kato I;Plummer M;Muñoz N;Canzian F
通讯作者：
Canzian F
影响因子：
--
作者：
Campa D;Vodicka P;Pardini B;Naccarati A;Carrai M;Vodickova L;Novotny J;Hemminki K;Försti A;Barale R;Canzian F
通讯作者：
Canzian F