A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer.
A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer.
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DOI：
10.1186/1471-2350-11-88
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发表时间：
2010-06-09
影响因子：
--
通讯作者：
Canzian F
中科院分区：
文献类型：
--
作者：
Campa D;Vodicka P;Pardini B;Naccarati A;Carrai M;Vodickova L;Novotny J;Hemminki K;Försti A;Barale R;Canzian F
胃肠道（GI）中的分子传感负责检测摄入的有害药物和毒素，因此影响启动这些反应的能力的遗传多态性可能对肠道消除对生物体的可能威胁的后续效率至关重要。虽然这些基本的控制系统已经知道了很长一段时间，最初的分子识别事件，感测的化学组成的胃肠道的管腔内容物仍然难以捉摸。TAS2R14是味觉受体家族中特征较好的成员之一，具有几种多态性变体。几种已被证明能激活TAS2R14的物质是强大的有毒和致癌物质。使用标签的方法，我们调查了所有常见的基因区域的遗传变异与结肠癌的风险与病例对照研究设计。据我们所知，这也是第一份关于高加索人群中该基因等位基因频率的报告。我们没有发现TAS2R14基因多态性与结肠癌风险之间存在统计学显著相关性的证据。总之，我们可以自信地排除TAS2R14基因常见多态性在该人群结直肠癌风险中的主要作用，尽管在本报告中，我们没有足够的统计学把握度完全排除TAS2R14罕见变异可能参与结直肠癌风险的可能性。
Molecular sensing in the gastro-intestinal (GI) tract is responsible for the detection of ingested harmful drugs and toxins, thereby genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of the gut in eliminating possible threats to the organism. Although these fundamental control systems have been known for long time, the initial molecular recognition events that sense the chemical composition of the luminal contents of the GI tract have remained elusive. TAS2R14 is one of the better characterized members of the taste receptor family and has several polymorphic variants. Several substances that have been shown to activate TAS2R14 are powerful toxic and carcinogenic agents. Using a tagging approach we investigated all the common genetic variation of the gene region in relation to colon cancer risk with a case-control study design. This is, at the best of our knowledge also the first report on the allele frequencies of the gene in the Caucasian population. We found no evidence of statistically significant associations between polymorphisms in the TAS2R14 gene and colon cancer risk. In conclusion we can confidently exclude a major role for common polymorphisms of the TAS2R14 gene in colorectal cancer risk in this population, although in this report we had insufficient statistical power to completely exclude the possibility that rare variants of the TAS2R14 might be involved in colorectal cancer risk.
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影响因子：
30.8
作者：
Bufe, B;Hofmann, T;Meyerhof, W
通讯作者：
Meyerhof, W
影响因子：
30.8
作者：
de Bakker, PIW;Yelensky, R;Altshuler, D
通讯作者：
Altshuler, D
影响因子：
3.1
作者：
Basson, MD;Bartoshuk, LM;Duffy, VB
通讯作者：
Duffy, VB
DOI：
10.1152/ajpgi.00073.2006
发表时间：
2006-08-01
影响因子：
4.5
作者：
Rozengurt, Enrique
通讯作者：
Rozengurt, Enrique
影响因子：
4.7
作者：
Vodicka, Pavel;Stetina, Rudolf;Hemminki, Kari
通讯作者：
Hemminki, Kari