Genetic variation in PSCA and risk of gastric advanced preneoplastic lesions and cancer in relation to Helicobacter pylori infection.
Genetic variation in PSCA and risk of gastric advanced preneoplastic lesions and cancer in relation to Helicobacter pylori infection.
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DOI：
10.1371/journal.pone.0073100
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Canzian F
中科院分区：
文献类型：
--
作者：
Rizzato C;Kato I;Plummer M;Muñoz N;Canzian F
一项全基因组关联研究发现，前列腺干细胞抗原 (PSCA) 基因中的 SNP 与胃癌 (GC) 风险相关。这种关联已在多个人群中得到复制。在本研究中，我们评估了 PSCA 基因型对晚期胃癌前病变和 GC 风险的影响。我们使用了基线胃组织病理学数据和来自参加委内瑞拉胃癌前病变化学预防试验的 2045 名受试者冷冻胃活检的 DNA，以及来自同一地区的 180 例 GC 病例。我们分析了 PSCA 基因中的 3 个 SNP（rs2294008、rs9297976 和 rs12155758），之前发现这些 SNP 与欧洲人的 GC 风险相关。 rs2294008 的 T 等位基因被发现与萎缩性胃炎（OR = 1.44；主要模型的 95% CI 1.03–2.01）和肠化生（OR = 1.50；主要模型的 95% CI 1.13–1.98）的患病率较高相关。我们还证实了与较高胃癌风险的关联（OR = 2.34；等位基因携带者的 95% CI 1.36–4.01）。 SNP rs12155758 与胃肿瘤前病变的风险无关，但我们证实其与较高的 GC 风险相关（OR 1.95；显性模型的 95% CI 1.29-2.97）。我们测试了幽门螺杆菌 cagA 基因存在的相关性，已知该基因会增加更严重胃部病变的风险，但我们没有发现与 PSCA SNP 在确定胃癌前病变或癌症风险方面有任何明确的相互作用。
SNPs in the Prostate Stem Cell Antigen (PSCA) gene have been found associated with gastric cancer (GC) risk in a genome-wide association study. This association has been replicated in several populations. In this study we assessed the impact of PSCA genotype on the risk of advanced gastric precancerous lesions and GC. We used baseline gastric histopathology data and DNA from frozen gastric biopsies of 2045 subjects enrolled in a chemoprevention trial for gastric precancerous lesions in Venezuela, and 180 cases of GC from the same area. We analyzed 3 SNPs in the PSCA gene (rs2294008, rs9297976 and rs12155758) which were previously found to be associated with GC risk in Europeans. The T allele of rs2294008 was found to be associated with a higher prevalence of atrophic gastritis (OR = 1.44; 95% CI 1.03–2.01 for the dominant model) and intestinal metaplasia (OR = 1.50; 95% CI 1.13–1.98 for the dominant model). We also confirmed the association with higher risk of gastric cancer (OR = 2.34; 95% CI 1.36–4.01 for the allele carriers). SNP rs12155758 was not associated with risk of gastric preneoplastic lesions, but we confirmed its association with higher GC risk (OR 1.95; 95% CI 1.29–2.97 for dominant model). We tested the relevance of the presence of the Helicobacter pylori cagA gene, which is known to increase the risk of more severe gastric lesions, but we did not find any clearcut interaction with PSCA SNPs in defining risk of gastric precancerous lesions or cancer.
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DOI：
10.2741/3320
发表时间：
2009-01-01
期刊：
Frontiers in bioscience (Landmark edition)
影响因子：
--
作者：
Mbulaiteye SM;Hisada M;El-Omar EM
通讯作者：
El-Omar EM
影响因子：
6.4
作者：
El-Etr, SH;Mueller, A;Merrell, DS
通讯作者：
Merrell, DS
影响因子：
3.1
作者：
Angel Chiurillo, Miguel;Moran, Yeinmy H.;Armanie, Emma
通讯作者：
Armanie, Emma
DOI：
10.1093/jnci/djm120
发表时间：
2007-09-05
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Plummer, Martyn;van Doorn, Leen-Jan;Kato, Ikuko
通讯作者：
Kato, Ikuko
白人前列腺干细胞抗原基因的遗传变异与上消化道癌。
影响因子：
29.4
作者：
Lochhead P;Frank B;Hold GL;Rabkin CS;Ng MT;Vaughan TL;Risch HA;Gammon MD;Lissowska J;Weck MN;Raum E;Müller H;Illig T;Klopp N;Dawson A;McColl KE;Brenner H;Chow WH;El-Omar EM
通讯作者：
El-Omar EM