Exosomes, the message transporters in vascular calcification.
Exosomes, the message transporters in vascular calcification.
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外泌体，血管钙化中的信息转运蛋白
DOI：
10.1111/jcmm.13692
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发表时间：
2018-09
影响因子：
5.3
通讯作者：
Huang H
中科院分区：
文献类型：
--
作者：
Zhang C;Zhang K;Huang F;Feng W;Chen J;Zhang H;Wang J;Luo P;Huang H
血管钙化（VC）是由羟磷灰石沉积在血管壁的内膜和中层引起的，可导致高血压、慢性肾脏病和糖尿病患者发生严重的心血管事件。VC的发生涉及复杂的机制网络，如基质囊泡或外泌体的产生、成骨分化、细胞活力降低、衰老等，然而，目前针对VC的治疗方法效果不佳，需要新的靶点来治疗VC。外泌体被证明参与VC并作为矿物沉积的初始化剂。还证明了装载有microRNA的分泌的外泌体调节受体血管平滑肌细胞中的VC加工。本文就外来体在VC过程中的作用，特别是其在细胞间生物信息传递中的作用作一综述。此外，我们将讨论外泌体在VC中的潜在机制。
Vascular calcification (VC) is caused by hydroxyapatite deposition in the intimal and medial layers of the vascular wall, leading to severe cardiovascular events in patients with hypertension, chronic kidney disease and diabetes mellitus. VC occurrences involve complicated mechanism networks, such as matrix vesicles or exosomes production, osteogenic differentiation, reduced cell viability, aging and so on. However, with present therapeutic methods targeting at VC ineffectively, novel targets for VC treatment are demanded. Exosomes are proven to participate in VC and function as initializers for mineral deposition. Secreted exosomes loaded with microRNAs are also demonstrated to modulate VC procession in recipient vascular smooth muscle cells. In this review, we targeted at the roles of exosomes during VC, especially at their effects on transporting biological information among cells. Moreover, we will discuss the potential mechanisms of exosomes in VC.
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作者：
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