Tryptophan metabolism in brain tumors - IDO and beyond.
Tryptophan metabolism in brain tumors - IDO and beyond.
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脑肿瘤中的色氨酸代谢-IDO及其他。
DOI：
10.1016/j.coi.2021.03.005
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发表时间：
2021-06
影响因子：
7
通讯作者：
Opitz CA
中科院分区：
文献类型：
--
作者：
Platten M;Friedrich M;Wainwright DA;Panitz V;Opitz CA
必需氨基酸色氨酸的代谢是限制抗肿瘤免疫的关键代谢途径，也是肿瘤免疫治疗的药物开发靶点。色氨酸代谢在包括胶质瘤在内的脑肿瘤中是活跃的，并促进恶性表型，并有助于免疫抑制的肿瘤微环境。近年来，对色氨酸代谢的调节和下游功能的了解已经显著地扩展到最初的体外观察，即吲哚胺-2，3-双加氧酶1(IDO1)促进细胞内色氨酸的耗竭。在这里，我们回顾了色氨酸代谢物在调节大脑功能和神经元完整性以及在脑肿瘤方面的具体作用。本文综述了近年来在确定关键调控因子以及色氨酸代谢的细胞和分子效应方面的最新进展，重点介绍了胶质瘤潜在的治疗靶点。
Metabolism of the essential amino acid tryptophan is a key metabolic pathway that restricts antitumor immunity and is a drug development target for cancer immunotherapy. Tryptophan metabolism is active in brain tumors including gliomas and promotes a malignant phenotype and contributes to the immunosuppressive tumor microenvironment. In recent years, improved understanding of the regulation and downstream function of tryptophan metabolism has been significantly expanded beyond the initial in vitro observation that the enzyme indoleamine-2,3-dioxygenase 1 (IDO1) promotes the depletion of intracellular tryptophan. Here, we revisit the specific roles of tryptophan metabolites in regulating brain functioning and neuronal integrity as well as in the context of brain tumors. This review summarizes recent developments in identifying key regulators, as well as the cellular and molecular effects of tryptophan metabolism with a particular focus on potential therapeutic targets in glioma
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
--
作者：
Litzenburger UM;Opitz CA;Sahm F;Rauschenbach KJ;Trump S;Winter M;Ott M;Ochs K;Lutz C;Liu X;Anastasov N;Lehmann I;Höfer T;von Deimling A;Wick W;Platten M
通讯作者：
Platten M
影响因子：
2.5
作者：
FOSTER, AC;VEZZANI, A;SCHWARCZ, R
通讯作者：
SCHWARCZ, R
DOI：
10.1158/1078-0432.ccr-19-3874
发表时间：
2020-10-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Ladomersky E;Zhai L;Lauing KL;Bell A;Xu J;Kocherginsky M;Zhang B;Wu JD;Podojil JR;Platanias LC;Mochizuki AY;Prins RM;Kumthekar P;Raizer JJ;Dixit K;Lukas RV;Horbinski C;Wei M;Zhou C;Pawelec G;Campisi J;Grohmann U;Prendergast GC;Munn DH;Wainwright DA
通讯作者：
Wainwright DA
影响因子：
3.2
作者：
John F;Michelhaugh SK;Barger GR;Mittal S;Juhász C
通讯作者：
Juhász C