Evaluation of the presence of B-cell attractant chemokines in chronic rhinosinusitis.
Evaluation of the presence of B-cell attractant chemokines in chronic rhinosinusitis.
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DOI：
10.2500/ajra.2010.24.3386
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发表时间：
2010-01
影响因子：
2.6
通讯作者：
Schleimer R
中科院分区：
文献类型：
--
作者：
Patadia M;Dixon J;Conley D;Chandra R;Peters A;Suh LA;Kato A;Carter R;Harris K;Grammer L;Kern R;Schleimer R
B-cell responses may play a role in the pathogenesis of nasal polyposis via local IgA and IgE production and activation of eosinophils and mast cells. B-cell attracting chemokines may therefore have relevance in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNPs) Polyp and inferior turbinate tissues were obtained from CRSwNPs, CRS without NPs (CRSsNPs), and control patients; ELISA and reverse-transcription polymerase chain reaction were used to detect levels of protein and mRNA for selected B-cell chemokines (B-cell attracting chemokine 1 [CXCL13/BCA-1/BLC]), thymus expressed chemokine (CCL25/TECK), mucosae-associated epithelial chemokine (CCL28/MEC), stromal cell–derived factor-1alpha (CXCL12/SDF-1alpha), and selected chemokine receptor genes (CXCR4, CXCR5, and CXCR7). BCA-1 and SDF-1alpha protein levels were significantly increased in polyp tissue compared with turbinate tissue from CRSsNP patients and controls (p < 0.05 and p < 0.01, respectively). Differences in TECK and MEC were not significant. For mRNA, expression of BCA-1 was significantly up-regulated in polyp tissue and levels correlated with CD20 mRNA expression. Additionally, significant up-regulation of mRNA for the SDF-1alpha receptors CXCR7 and CXCR4 was detected in polyps, while there was a trend for up-regulation of the BCA-1 receptor CXCR5. Elevated levels of the BCA-1 and SDF-1alpha and their receptors may account for an increased presence of B cells and their products, contributing to eosinophilic inflammation in patients with CRSwNP.
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影响因子：
4.4
作者：
Feng, Ningguo;Jaimes, Maria C.;Greenberg, Harry B.
通讯作者：
Greenberg, Harry B.
影响因子：
14.2
作者：
Bachert, C;Wagenmann, M;Rudack, C
通讯作者：
Rudack, C
影响因子：
14.2
作者：
Kato, Atsushi;Peters, Anju;Schleimer, Robert P.
通讯作者：
Schleimer, Robert P.
影响因子：
15.3
作者：
Ansel, K M;McHeyzer-Williams, L J;Ngo, V N;McHeyzer-Williams, M G;Cyster, J G
通讯作者：
Cyster, J G
影响因子：
4.4
作者：
Lazarus, NH;Kunkel, EJ;Butcher, EC
通讯作者：
Butcher, EC