Integrating memories in the human brain: hippocampal-midbrain encoding of overlapping events.
Integrating memories in the human brain: hippocampal-midbrain encoding of overlapping events.
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DOI：
10.1016/j.neuron.2008.09.023
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发表时间：
2008-10-23
期刊：
影响因子：
16.2
通讯作者：
Wagner, Anthony D.
中科院分区：
文献类型：
--
作者：
Shohamy, Daphna;Wagner, Anthony D.
Decisions are often guided by generalizing from past experiences. Fundamental questions remain regarding the cognitive and neural mechanisms by which generalization takes place. Prior data suggest that generalization may stem from inference-based processes that occur at the time of generalization. By contrast, it has been hypothesized that generalization may emerge from mnemonic processes that occur while premise events are being encoded. Here, participants engaged in a two-phase learning and generalization task, wherein they initially learned a series of overlapping associations, and were subsequently probed to generalize what they learned to novel stimulus combinations. Functional magnetic resonance imaging (fMRI) revealed that subsequent generalization performance was associated with coupled changes in learning-phase activity in the hippocampus and midbrain (ventral tegmental area/substantia nigra). These findings provide novel evidence for generalization based on integrative encoding, whereby overlapping past events are integrated into a linked mnemonic representation. Hippocampal–midbrain interactions support the dynamic integration of experiences, providing a powerful mechanism for building a rich associative history that extends beyond individually experienced events.
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DOI：
10.1073/pnas.94.13.7109
发表时间：
1997-06-24
影响因子：
11.1
作者：
Dusek, JA;Eichenbaum, H
通讯作者：
Eichenbaum, H
影响因子：
2.5
作者：
Aron, AR;Shohamy, D;Poldrack, RA
通讯作者：
Poldrack, RA
影响因子：
16.2
作者：
Bunzeck, Nico;Duzel, Emrah
通讯作者：
Duzel, Emrah
DOI：
10.1037/0097-7403.19.4.391
发表时间：
1993-10-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
影响因子：
--
作者：
HALL, G;RAY, E;BONARDI, C
通讯作者：
BONARDI, C
影响因子：
2.9
作者：
FREY, U;SCHROEDER, H;MATTHIES, H
通讯作者：
MATTHIES, H