Translational regulation in response to stress in Saccharomyces cerevisiae.
Translational regulation in response to stress in Saccharomyces cerevisiae.
复制标题
酿酒酵母的压力的翻译调节。
DOI：
10.1002/yea.3349
复制
发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Pavitt GD
中科院分区：
文献类型：
--
作者：
Crawford RA;Pavitt GD
芽殖酵母酿酒酵母必须动态改变其蛋白质组的组成，以应对不同的压力。应激期间基因表达的重编程通常涉及蛋白质合成的初始全局抑制，伴随着通过翻译和转录反应激活应激反应mRNA。因此，特异性mRNA对抗全局翻译抑制的能力对于对应激的整体反应至关重要。本文总结了S.啤酒。总之，大量的研究表明，多种因素协同作用，以带来适当的翻译反应。这些包括mRNA内的调节元件，改变mRNA与RNA结合蛋白的相互作用以及核糖体的特化，每个都有助于调节蛋白质表达以适应不断变化的环境条件。
The budding yeast Saccharomyces cerevisiae must dynamically alter the composition of its proteome in order to respond to diverse stresses. The reprogramming of gene expression during stress typically involves initial global repression of protein synthesis, accompanied by the activation of stress‐responsive mRNAs through both translational and transcriptional responses. The ability of specific mRNAs to counter the global translational repression is therefore crucial to the overall response to stress. Here we summarize the major repressive mechanisms and discuss mechanisms of translational activation in response to different stresses in S. cerevisiae. Taken together, a wide range of studies indicate that multiple elements act in concert to bring about appropriate translational responses. These include regulatory elements within mRNAs, altered mRNA interactions with RNA‐binding proteins and the specialization of ribosomes that each contribute towards regulating protein expression to suit the changing environmental conditions.
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影响因子：
7.8
作者：
Buchan, J. Ross;Muhlrad, Denise;Parker, Roy
通讯作者：
Parker, Roy
影响因子：
3.7
作者：
Bodi Z;Bottley A;Archer N;May ST;Fray RG
通讯作者：
Fray RG
DOI：
10.1016/j.tem.2015.09.012
发表时间：
2015-12
期刊：
Trends in endocrinology and metabolism: TEM
影响因子：
--
作者：
Castello A;Hentze MW;Preiss T
通讯作者：
Preiss T
影响因子：
16.6
作者：
Beckmann BM;Horos R;Fischer B;Castello A;Eichelbaum K;Alleaume AM;Schwarzl T;Curk T;Foehr S;Huber W;Krijgsveld J;Hentze MW
通讯作者：
Hentze MW
影响因子：
4.5
作者：
Beilharz, Traude H.;Preiss, Thomas
通讯作者：
Preiss, Thomas