Non-Nutritive Sweetened Beverages Impair Therapeutic Benefits of Metformin in Prediabetic Diet-Induced Obese Mice.
Non-Nutritive Sweetened Beverages Impair Therapeutic Benefits of Metformin in Prediabetic Diet-Induced Obese Mice.
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DOI：
10.3390/nu15112472
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发表时间：
2023-05-25
期刊：
影响因子：
5.9
通讯作者：
de Lartigue G
中科院分区：
文献类型：
--
作者：
Singh A;Rourk K;Bernier A;de Lartigue G
二甲双胍是一种治疗2型糖尿病和相关代谢性疾病的一线疗法，结果多种多样。本研究旨在调查含糖饮料(卡路里或非卡路里)是否影响二甲双胍在饮食诱导肥胖中对血糖、食物摄入量和体重减轻的治疗效果。小鼠被给予高脂饮食和加糖水8周，以诱导肥胖和糖耐量异常。然后，小鼠被随机分成两组，分别在水、高果糖玉米糖浆(HFCS)或非营养甜味剂糖精中服用二甲双胍6周。治疗6周后，与治疗前相比，所有组的糖耐量均有改善。然而，糖精导致的糖耐量和体重增加结果比水或HFCS组更差，并与较低的血浆生长分化因子15水平相关。综上所述，建议在二甲双胍治疗期间减少非营养性甜味剂的消耗，以避免损害二甲双胍对体重和血糖稳态的治疗效果。
Metformin, a frontline therapy for type 2 diabetes and related metabolic diseases, results in variable outcomes. This study aimed to investigate whether sweetened beverages (caloric or non-caloric) affect the therapeutic benefits of metformin on glucose, food intake, and weight loss in diet-induced obesity. Mice were given a high-fat diet and sweetened water for 8 weeks to induce obesity and glucose intolerance. Then, mice were randomized to receive metformin in either water, high-fructose corn syrup (HFCS), or the non-nutritive sweetener saccharin for 6 weeks. After 6 weeks of metformin treatment, all groups had improved glucose tolerance compared to pretreatment. However, saccharin resulted in worse glucose tolerance and weight gain outcomes than the water or HFCS groups and correlated with lower plasma growth differentiation factor 15 levels. In conclusion, reducing non-nutritive sweetener consumption during metformin therapy is recommended to avoid impairing the therapeutic effects of metformin on body weight and glucose homeostasis.
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影响因子：
82.9
作者：
Emmerson, Paul J.;Wang, Feng;Wu, Xinle
通讯作者：
Wu, Xinle
DOI：
10.1136/bmj.h3576
发表时间：
2015-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Imamura F;O'Connor L;Ye Z;Mursu J;Hayashino Y;Bhupathiraju SN;Forouhi NG
通讯作者：
Forouhi NG
影响因子：
64.5
作者：
Suez, Jotham;Cohen, Yotam;Elinav, Eran
通讯作者：
Elinav, Eran
影响因子：
105.7
作者：
Debras, Charlotte;Chazelas, Eloi;Sellem, Laury;Porcher, Raphael;Druesne-Pecollo, Nathalie;Esseddik, Younes;de Edelenyi, Fabien Szabo;Agaesse, Cedric;De Sa, Alexandre;Lutchia, Rebecca;Fezeu, Leopold K.;Julia, Chantal;Kesse-Guyot, Emmanuelle;Alles, Benjamin;Galan, Pilar;Hercberg, Serge;Deschasaux-Tanguy, Melanie;Huybrechts, Inge;Srour, Bernard;Touvier, Mathilde
通讯作者：
Touvier, Mathilde
影响因子：
7.7
作者：
Kim, YW;Kim, JY;Moon, KH
通讯作者：
Moon, KH