Nodular and diffuse types of lymphocyte predominance Hodgkin's disease.
Nodular and diffuse types of lymphocyte predominance Hodgkin's disease.
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结节型和弥漫型淋巴细胞为主的霍奇金病。
DOI：
10.1056/nejm198801283180404
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Weiss,LM
中科院分区：
文献类型：
--
作者：
RegulaJr,DP;Hoppe,RT;Weiss,LM
淋巴细胞占优势的结节型霍奇金病已被证明是免疫表型不同于组织学弥漫型和其他类型的霍奇金病。我们对73例进行了临床病理学研究，以确定结节性和弥漫性亚型之间是否存在任何临床差异。弥漫型患者（n = 41）的病程往往与其他类型的霍奇金病相似;很少复发，只有两例死于霍奇金病。相比之下，结节型患者（n = 32）有显着更多的复发，这是独立的阶段或治疗，平均分布到10年后的初始治疗。尽管经常复发，结节型患者的病程缓慢，只有1例死于霍奇金病。有七个致命的第二癌症和两个非肿瘤治疗相关的死亡，平均分布在结节和弥漫性groups.We的结论，结节淋巴细胞为主的霍奇金病可能有重要的临床和免疫表型的差异，从其他形式的霍奇金病，这种情况下的患者应仔细随访，因为晚期复发的可能性。（N Engl J Med 1988; 318：214-9.）
The nodular form of lymphocyte predominance Hodgkin's disease has been shown to be immunophenotypically distinct from the histologically diffuse form and from other types of Hodgkin's disease. We undertook a clinicopathological study of 73 cases to determine whether any clinical differences between the nodular and diffuse subtypes could be discerned. Patients with the diffuse form (n = 41) tended to have a course similar to that of other types of Hodgkin's disease; there were few relapses and only two deaths due to Hodgkin's disease. In contrast, patients with the nodular form (n = 32) had significantly more relapses, which were independent of stage or treatment and equally distributed up to 10 years after initial therapy. Despite the frequent relapses, patients with the nodular form had an indolent course, and there was only one death due to Hodgkin's disease. There were seven fatal second cancers and two non-neoplastic treatment-related deaths, equally distributed between the nodular and diffuse groups.We conclude that nodular lymphocyte predominance Hodgkin's disease may have important clinical as well as immunophenotypic differences from other forms of Hodgkin's disease, and that patients with this condition should be followed carefully because of the possibility of late relapse. (N Engl J Med 1988; 318:214–9.)
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影响因子：
45.3
作者：
ACKER, B;HOPPE, RT;ROSENBERG, SA
通讯作者：
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作者：
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DOI：
--
发表时间：
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期刊：
Virchows Archiv B Cell Pathology Including Molecular Pathology
影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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