Toll-like receptor 5 (TLR5) expression is a novel predictive marker for recurrence and survival in squamous cell carcinoma of the tongue.
Toll-like receptor 5 (TLR5) expression is a novel predictive marker for recurrence and survival in squamous cell carcinoma of the tongue.
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DOI：
10.1038/bjc.2012.589
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发表时间：
2013-02-19
影响因子：
8.8
通讯作者：
Salo, T.
中科院分区：
文献类型：
--
作者：
Kauppila, J. H.;Mattila, A. E.;Karttunen, T. J.;Salo, T.
toll样受体5 （TLR5）是一种识别细菌鞭毛蛋白的免疫受体。TLR5的激活导致癌症侵袭和细胞因子的释放。由于某些细菌与口腔癌有关，我们想研究TLR5在口腔舌鳞状细胞癌（OTSCC）中的表达。本文收集了119例OTSCC患者的标本，其中101例为邻近正常舌黏膜标本。采用免疫组化盲法半定量评估TLR5组织评分（0-300）。toll样受体5在84例正常上皮和118例癌样上皮中表达。与正常舌上皮相比，TLR5在癌组织中的表达增加（中位组织评分15比135）。在癌症中，较高的TLR5与诊断时的年龄、女性性别和疾病复发有关。TLR5表达与肿瘤分级、分期或治疗没有关联。在多变量分析中，TLR5是癌症死亡率（危险比（HR） 3.587, 95%可信区间（CI） 1.632-7.882）和疾病复发率（HR 4.455, 95% CI(2.168-9.158)）的独立预测因子。toll样受体5在OTSCC的病理生理中具有先前未描述的作用，可能代表细菌和癌症之间的联系。它可能是预测OTSCC患者复发或生存的有用指标。
Toll-like receptor 5 (TLR5) is an immune receptor recognising bacterial flagellin. Activation of TLR5 results in cancer invasion and cytokine release. As certain bacteria have been linked to oral cancer, we wanted to study TLR5 expression in oral tongue squamous cell carcinoma (OTSCC). Samples from 119 patients with OTSCC were obtained, including 101 samples of adjacent normal lingual mucosa. The TLR5 histoscore (0–300) was assessed semiquantitatively by immunohistochemistry in a blinded manner. Toll-like receptor 5 was expressed in 84 normal epithelia and 118 cancer samples. Expression of TLR5 was increased in cancer when compared with normal lingual epithelium (median histoscore 15 vs 135). In cancer, higher TLR5 was associated with age of >70 years at the time of diagnosis, female gender and disease recurrence. No association between TLR5 expression and tumour grade, stage or treatment was found. In multivariate analysis, TLR5 was an independent predictor of cancer mortality (hazard ratio (HR) 3.587, 95% confidence interval (CI) (1.632–7.882)) and disease recurrence (HR 4.455, 95% CI (2.168–9.158)). Toll-like receptor 5 has a previously undescribed role in the pathophysiology of OTSCC and might represent a link between bacteria and cancer. It could be a useful marker for predicting recurrence or survival of OTSCC patients.
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