Therapeutic Potential of Endothelial Colony-Forming Cells in Ischemic Disease: Strategies to Improve their Regenerative Efficacy.
Therapeutic Potential of Endothelial Colony-Forming Cells in Ischemic Disease: Strategies to Improve their Regenerative Efficacy.
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DOI：
10.3390/ijms21197406
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发表时间：
2020-10-07
影响因子：
5.6
通讯作者：
Moccia F
中科院分区：
文献类型：
--
作者：
Faris P;Negri S;Perna A;Rosti V;Guerra G;Moccia F
心血管疾病（CVD）包括一系列主要的临床心脏和循环系统疾病，在世界范围内产生巨大的健康和经济负担。目前，血管再生手术是治疗缺血性疾病最常用的治疗方法，尽管并非所有患者都适合手术血运重建。因此，迫切需要更有效的治疗方法来促进新血管形成。治疗性血管生成代表了一种新兴的策略，其目的在于通过刺激局部血管生成和/或根据称为血管发生的过程促进从头血管形成来重建受损的血管网络。反过来，循环内皮集落形成细胞（ECFC）代表真正的内皮前体细胞，它显示出高克隆形成潜力，并有记录的能力，在体内从头血管。因此，ECFC被认为是最有前途的细胞候选人，以促进治疗性血管生成的患者患有CVD。目前简要总结了有关ECFC起源和特征的可用信息，然后广泛说明了评估其在各种缺血性疾病（包括急性心肌梗死、外周动脉疾病、缺血性脑疾病和视网膜病变）中的再生功效的临床前研究。然后，我们描述了最常见的药理学，遗传学和表观遗传学策略，用于通过操纵关键的促血管生成信号通路来增强自体ECFC的血管修复潜力，例如，细胞外信号调节激酶/Akt、磷酸肌醇3-激酶和Ca 2+信号传导。最后，我们讨论了靶向循环ECFC拯救其功能障碍的表型和促进新血管形成的CVD存在的可能性。
Cardiovascular disease (CVD) comprises a range of major clinical cardiac and circulatory diseases, which produce immense health and economic burdens worldwide. Currently, vascular regenerative surgery represents the most employed therapeutic option to treat ischemic disorders, even though not all the patients are amenable to surgical revascularization. Therefore, more efficient therapeutic approaches are urgently required to promote neovascularization. Therapeutic angiogenesis represents an emerging strategy that aims at reconstructing the damaged vascular network by stimulating local angiogenesis and/or promoting de novo blood vessel formation according to a process known as vasculogenesis. In turn, circulating endothelial colony-forming cells (ECFCs) represent truly endothelial precursors, which display high clonogenic potential and have the documented ability to originate de novo blood vessels in vivo. Therefore, ECFCs are regarded as the most promising cellular candidate to promote therapeutic angiogenesis in patients suffering from CVD. The current briefly summarizes the available information about the origin and characterization of ECFCs and then widely illustrates the preclinical studies that assessed their regenerative efficacy in a variety of ischemic disorders, including acute myocardial infarction, peripheral artery disease, ischemic brain disease, and retinopathy. Then, we describe the most common pharmacological, genetic, and epigenetic strategies employed to enhance the vasoreparative potential of autologous ECFCs by manipulating crucial pro-angiogenic signaling pathways, e.g., extracellular-signal regulated kinase/Akt, phosphoinositide 3-kinase, and Ca2+ signaling. We conclude by discussing the possibility of targeting circulating ECFCs to rescue their dysfunctional phenotype and promote neovascularization in the presence of CVD.
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影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
5.4
作者：
Bouvard C;Galy-Fauroux I;Grelac F;Carpentier W;Lokajczyk A;Gandrille S;Colliec-Jouault S;Fischer AM;Helley D
通讯作者：
Helley D
影响因子：
9.8
作者：
Benslimane-Ahmim, Zahia;Poirier, Florence;Boisson-Vidal, Catherine
通讯作者：
Boisson-Vidal, Catherine
影响因子：
20.3
作者：
Au, Patrick;Daheron, Laurence M.;Jain, Rakesh K.
通讯作者：
Jain, Rakesh K.
DOI：
10.1083/jcb.139.1.265
发表时间：
1997-10-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bloch W;Forsberg E;Lentini S;Brakebusch C;Martin K;Krell HW;Weidle UH;Addicks K;Fässler R
通讯作者：
Fässler R