Associations of serum vitamins levels with bone mineral density in the different race-ethnicities US adults.
Associations of serum vitamins levels with bone mineral density in the different race-ethnicities US adults.
复制标题
美国成年人不同种族种族中血清维生素与骨矿物质密度的关联。
DOI：
10.1186/s12891-021-03997-0
复制
发表时间：
2021-02-04
影响因子：
2.3
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Li X;Liu X
关于特定维生素水平与骨密度（BMD）相关性的结论存在争议。因此，本研究的目的是检查血清维生素水平与BMD的相关性，以及种族/民族对美国成年人这些相关性的改良效应。这项研究来自第三次全国健康和营养调查。所有年龄≥18岁且数据完整的受试者均合格。使用Quantaphase II放射性测定试剂盒（Bio-Rad）测定血清维生素A、B 9、B12、C和E水平。采用双能X线骨密度仪测量股骨颈和全髋骨密度。最终分析纳入6023名参与者。血清叶酸、维生素A和C水平与BMD呈正相关。未观察到血清维生素B12和E水平与BMD的显著相关性。血清叶酸水平与糖尿病肾病的发生率呈正相关，（β = 0.00027和0.00032; 95%CI：0.00002-0.00057和0.00002-0.00063），维生素A水平（β = 0.01132和0.01115; 95%CI分别为0.00478-0.01787和0.00430-0.01799），维生素C水平（β = 0.00027和0.00029; 95% CI分别为：0.00012-0.00042和0.00013-0.00045），仅在非西班牙裔受试者中进行股骨颈和全髋关节BMD检查。血清叶酸、维生素A和C水平升高与较高的BMD相关。此外，性别和种族/民族改变了血清维生素水平与BMD的关系。
The conclusions on the associations of specific vitamin levels with bone mineral density (BMD) were controversial. Therefore, the aims of this study were to examine the associations of serum vitamins levels with BMD and the modified effect of race/ ethnicity on these associations in the US adults. This study was from the third National Health and Nutrition Examination Survey. All participants aged ≥18 years with complete data were eligible. Serum vitamins A, B9, B12, C, and E levels were assayed using the Quantaphase II Radioassay Kit (Bio-Rad). Dual-energy X-ray absorptiometry was employed to measure BMD, including femur neck and the total hip. There were 6023 participants included in the final analysis. Serum folate, vitamins A and C levels were positively associated with BMD. No significant associations of serum vitamins B12 and E levels with BMD were observed. There were positive associations of serum folate level (β = 0.00027 and 0.00032; and 95% CI: 0.00002–0.00057 and 0.00002–0.00063, respectively), vitamin A level (β = 0.01132 and 0.01115; and 95% CI: 0.00478–0.01787 and 0.00430–0.01799, respectively), and vitamin C level (β = 0.00027 and 0.00029; and 95% CI: 0.00012–0.00042 and 0.00013–0.00045, respectively) with BMD at femur neck and the total hip only in the Not Hispanic participants. Elevated serum folate, vitamins A and C levels were associated with a higher BMD. Furthermore, sex and race/ ethnicity modified the associations of serum vitamins levels with BMD.
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影响因子：
4.1
作者：
Maggio, D;Polidori, MC;Cherubini, A
通讯作者：
Cherubini, A
影响因子：
6.2
作者：
Burge, Russel;Dawson-Hughes, Bess;Tosteson, Anna
通讯作者：
Tosteson, Anna
影响因子：
4
作者：
Lippuner, Kurt;Golder, Matthias;Greiner, Roger
通讯作者：
Greiner, Roger
影响因子：
6.8
作者：
Herrmann, Markus;Umanskaya, Natalia;Herrmann, Wolfgang
通讯作者：
Herrmann, Wolfgang
影响因子：
7.1
作者：
Bailey, Regan L.;Looker, Anne C.;Mills, James L.
通讯作者：
Mills, James L.