Effect of Viewing Conditions on Fixation Eye Movements and Eye Alignment in Amblyopia.
Effect of Viewing Conditions on Fixation Eye Movements and Eye Alignment in Amblyopia.
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DOI：
10.1167/iovs.63.2.33
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发表时间：
2022-02-01
影响因子：
4.4
通讯作者：
Ghasia FF
中科院分区：
文献类型：
--
作者：
Murray J;Gupta P;Dulaney C;Garg K;Shaikh AG;Ghasia FF
弱视患者的注视不稳定性是由生理性注视眼运动（FEM）和眼球震颤的改变引起的。我们评估了单眼、双眼和双眼分视对伴有和不伴有融合性发育不良性眼球震颤（FMN）患者的FEMs和眼球排列的影响。本研究招募了34名弱视患者和7名健康对照。在不同的对侧眼（FE）对比度下，使用红外视频眼电描记术记录（1）对侧眼观察（FEV）、（2）弱视眼观察（AEV）、（3）双眼观察（BEV）和（4）双眼分视观察（DcV）期间的眼球运动。根据弱视的临床类型和FEM波形将患者分为无眼球震颤组、眼球震颤伴和不伴FMN组。分析FE眼和弱视眼的注视扫视和扫视间漂移、眼球震颤的快相和慢相以及双变量轮廓椭圆面积。我们发现，FEMs的差异影响，增加幅度的快速阶段的FMN观察在AEV比BEV和DcV在较低的FE对比度。在较低FE对比度下，屈光参差患者的固定不稳定性增加。伴随着眼位不正，FEV增加最多。无FMN的斜视/混合性弱视患者比FMN患者更可能在DcV期间表现出注视转换，其中AE关注目标。我们的研究结果表明，FEM异常调制与不同的观看条件下使用的各种弱视治疗。FEM异常增加可能影响视功能缺陷，并可能具有治疗意义。
Patients with amblyopia are known to have fixation instability, which arises from alteration of physiologic fixation eye movements (FEMs) and nystagmus. We assessed the effects of monocular, binocular, and dichoptic viewing on FEMs and eye alignment in patients with and without fusion maldevelopment nystagmus (FMN). Thirty-four patients with amblyopia and seven healthy controls were recruited for this study. Eye movements were recorded using infrared video-oculography during (1) fellow eye viewing (FEV), (2) amblyopic eye viewing (AEV), (3) both eye viewing (BEV), and (4) dichoptic viewing (DcV) at varying fellow eye (FE) contrasts. The patients were classified per the clinical type of amblyopia and FEM waveforms into those without nystagmus, those with nystagmus with and without FMN. Fixational saccades and intersaccadic drifts, quick and slow phases of nystagmus, and bivariate contour ellipse area were analyzed in the FE and amblyopic eye (AE). We found that FEMs are differentially affected with increased amplitude of quick phases of FMN observed during AEV than BEV and during DcV at lower FE contrasts. Increased fixation instability was seen in anisometropic patients at lower FE contrasts. Incomitance of eye misalignment was seen with the greatest increase during FEV. Strabismic/mixed amblyopia patients without FMN were more likely to demonstrate a fixation switch where the AE attends to the target during DcV than patients with FMN. Our findings suggest that FEM abnormalities modulate with different viewing conditions as used in various amblyopia therapies. Increased FEM abnormalities could affect the visual function deficits and may have treatment implications.
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影响因子：
3.4
作者：
Alexander RG;Macknik SL;Martinez-Conde S
通讯作者：
Martinez-Conde S
DOI：
10.1126/science.1166112
发表时间：
2009-02-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hafed ZM;Goffart L;Krauzlis RJ
通讯作者：
Krauzlis RJ
影响因子：
4.1
作者：
Ghasia, Fatema F.;Otero-Millan, Jorge;Shaikh, Aasef G.
通讯作者：
Shaikh, Aasef G.
影响因子：
--
作者：
DELLOSSO, LF;FLYNN, JT
通讯作者：
FLYNN, JT
影响因子：
13.7
作者：
Holmes, Jonathan M.;Manny, Ruth E.;Wallace, David K.
通讯作者：
Wallace, David K.