Schwann Cell Responses and Plasticity in Different Dental Pulp Scenarios.
Schwann Cell Responses and Plasticity in Different Dental Pulp Scenarios.
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DOI：
10.3389/fncel.2018.00299
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发表时间：
2018
影响因子：
5.3
通讯作者：
Schmachtenberg O
中科院分区：
文献类型：
--
作者：
Couve E;Schmachtenberg O
哺乳动物的牙齿已经进化为牙本质单位，其包含复杂的感觉神经支配系统以保护和保存其结构和功能。在人类牙髓（DP）中，机械感觉纤维和伤害感受纤维在冠状牙本质-牙髓界面处形成神经末梢的密集网络，所述神经末梢来自Raschkow丛（RP）的有髓和无髓轴突。雪旺细胞（SC）在这些纤维损伤后的支持，维护和再生中起着至关重要的作用。我们最近的特点是两个SC表型层次组织内的冠状和根DP在人类牙齿。髓鞘形成和非髓鞘形成SC（nmSCs）显示与伤害性C纤维发芽和轴突变性相关的高度可塑性，以响应牙本质龋或生理性根吸收（PRR）引起的DP损伤。通过比较免疫标记，共聚焦和电子显微镜，我们的特点是短期适应性反应的SC表型神经损伤，和长期的变化与老化。SC的增加表征了与受影响的DP域中的轴突发芽相关的对龋齿进展的早期反应。此外，在PRR期间，观察到Büngner带的形成作为SC修复轨道功能的一部分。另一方面，有髓轴突密度随着牙龄显著降低，这是DP防御和修复能力逐渐降低的一部分。SC在不同牙科场景中保持DP神经支配的显着可塑性和能力构成了改善临床治疗的基本方面。这篇综述文章讨论了髓鞘和非mSCs在长期牙齿保存和体内平衡中的核心作用。
Mammalian teeth have evolved as dentin units that enclose a complex system of sensory innervation to protect and preserve their structure and function. In human dental pulp (DP), mechanosensory and nociceptive fibers form a dense meshwork of nerve endings at the coronal dentin-pulp interface, which arise from myelinated and non-myelinated axons of the Raschkow plexus (RP). Schwann cells (SCs) play a crucial role in the support, maintenance and regeneration after injury of these fibers. We have recently characterized two SC phenotypes hierarchically organized within the coronal and radicular DP in human teeth. Myelinating and non-myelinating SCs (nmSCs) display a high degree of plasticity associated with nociceptive C-fiber sprouting and axonal degeneration in response to DP injuries from dentin caries or physiological root resorption (PRR). By comparative immunolabeling, confocal and electron microscopy, we have characterized short-term adaptive responses of SC phenotypes to nerve injuries, and long-term changes related to aging. An increase of SCs characterizes the early responses to caries progression in association with axonal sprouting in affected DP domains. Moreover, during PRR, the formation of bands of Büngner is observed as part of SC repair tracks functions. On the other hand, myelinated axon density is significantly reduced with tooth age, as part of a gradual decrease in DP defense and repair capacities. The remarkable plasticity and capacity of SCs to preserve DP innervation in different dental scenarios constitutes a fundamental aspect to improve clinical treatments. This review article discusses the central role of myelinating and non-mSCs in long-term tooth preservation and homeostasis.
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DOI：
10.1083/jcb.201205025
发表时间：
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期刊：
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影响因子：
--
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影响因子：
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作者：
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DOI：
10.1111/ajt.14515
发表时间：
2018-03
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
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作者：
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