Three-dimensional cardiac computational modelling: methods, features and applications.
Three-dimensional cardiac computational modelling: methods, features and applications.
复制标题
DOI：
10.1186/s12938-015-0033-5
复制
发表时间：
2015-04-17
影响因子：
3.9
通讯作者：
Ferrero JM
中科院分区：
文献类型：
--
作者：
Lopez-Perez A;Sebastian R;Ferrero JM
计算模型和生物物理模拟的结合可以帮助解释一系列实验数据，并有助于理解，诊断和治疗复杂的疾病，如心律失常。出于这个原因，三维（3D）心脏计算建模目前是一个新兴的研究领域。在过去的几十年里，医学成像技术的进步已经允许从通用到患者特定的3D心脏模型的演变，这些模型忠实地表示给定活体受试者的解剖结构和不同的心脏特征。在这里，我们分析了60个代表性的3D心脏计算模型开发和出版在过去的50年中，描述他们的信息来源，功能，开发方法和在线可用性。本文还回顾了必要的组件，以建立一个三维计算模型的心脏，旨在生物物理模拟，特别注意心脏电生理（EP），并将这些组件的现有方法。我们评估了与构建过程的不同步骤相关的挑战，从原始临床或生物数据的处理到最终应用，包括图像分割，包含子结构和网格等。我们简要概述了目前在3D心脏计算建模中可用的个性化方法。最后，我们提出了几个具体的应用程序，主要涉及心脏EP模拟和基于模型的图像分析的例子，显示了潜在的有用性的三维心脏计算建模到临床环境作为一种工具，以帮助预防，诊断和治疗心脏疾病。本文的在线版本（doi：10.1186/s12938-015-0033-5）包含补充材料，可供授权用户使用。
The combination of computational models and biophysical simulations can help to interpret an array of experimental data and contribute to the understanding, diagnosis and treatment of complex diseases such as cardiac arrhythmias. For this reason, three-dimensional (3D) cardiac computational modelling is currently a rising field of research. The advance of medical imaging technology over the last decades has allowed the evolution from generic to patient-specific 3D cardiac models that faithfully represent the anatomy and different cardiac features of a given alive subject. Here we analyse sixty representative 3D cardiac computational models developed and published during the last fifty years, describing their information sources, features, development methods and online availability. This paper also reviews the necessary components to build a 3D computational model of the heart aimed at biophysical simulation, paying especial attention to cardiac electrophysiology (EP), and the existing approaches to incorporate those components. We assess the challenges associated to the different steps of the building process, from the processing of raw clinical or biological data to the final application, including image segmentation, inclusion of substructures and meshing among others. We briefly outline the personalisation approaches that are currently available in 3D cardiac computational modelling. Finally, we present examples of several specific applications, mainly related to cardiac EP simulation and model-based image analysis, showing the potential usefulness of 3D cardiac computational modelling into clinical environments as a tool to aid in the prevention, diagnosis and treatment of cardiac diseases. The online version of this article (doi:10.1186/s12938-015-0033-5) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
3.8
作者：
Bayer, J. D.;Blake, R. C.;Plank, G.;Trayanova, N. A.
通讯作者：
Trayanova, N. A.
DOI：
10.1196/annals.1380.023
发表时间：
2006-01-01
期刊：
INTERACTIVE AND INTEGRATIVE CARDIOLOGY
影响因子：
--
作者：
Burton, Rebecca A. B.;Plank, Gernot;Kohl, Peter
通讯作者：
Kohl, Peter
影响因子：
10.8
作者：
Clancy, CE;Rudy, Y
通讯作者：
Rudy, Y
影响因子：
2
作者：
Aliev, RR;Panfilov, AV
通讯作者：
Panfilov, AV
影响因子：
3.8
作者：
Boyle, Patrick M.;Deo, Makarand;Vigmond, Edward J.
通讯作者：
Vigmond, Edward J.