Cytokine-mediated cellular immune activation in electroconvulsive therapy: A CSF study in patients with treatment-resistant depression
Cytokine-mediated cellular immune activation in electroconvulsive therapy: A CSF study in patients with treatment-resistant depression
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电休克治疗中细胞因子介导的细胞免疫激活：针对难治性抑郁症患者的脑脊液研究
DOI：
10.1080/15622975.2019.1618494
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Kranaster L
中科院分区：
文献类型：
--
作者：
Mindt S;Neumaier M;Hoyer C;Sartorius A;Kranaster L
目的：有证据表明，电休克治疗（ECT）的抗抑郁作用与免疫系统的调节之间存在重要关系。为了进一步阐明这种相互作用，我们进行了一项研究，研究了ECT抗抑郁治疗对抑郁症患者25种细胞因子的影响。方法：我们测量了25种不同的细胞因子（白细胞介素（IL）-1β、IL-1 RA、IL-2、IL-2 R、IL-4、IL-5、IL-6、IL-7、IL-8、IL-10、IL-12（p40/p70）、IL-13、IL-15、IL-17、肿瘤坏死因子-α、干扰素（IFN）-α、IFN-γ、粒细胞-巨噬细胞集落刺激因子，巨噬细胞炎性蛋白（MIP）-1α，MIP-1β，IFN-γ诱导蛋白10（IP-10），IFN-γ诱导的单核因子，嗜酸性粒细胞趋化因子，Rantes和单核细胞趋化蛋白1）在脑脊液（CSF）和血液中的12例严重和治疗-结果：ECT治疗后CSF中IP-10、IL-5和IL-8水平升高，ECT治疗次数越多，治疗前后CSF中IFN-γ、IL-2 RA、Rantes、IL-6和IL-1β水平的差异越大。ECT治疗期间，应答者和/或缓解者CSF中IL-17、MIP-1α、Rantes和IL-2 R水平均降低。CSF IP-10水平增加较少ECT期间的患者谁有一个resultation.Conclusions：虽然样本量小，我们发现不同的影响ECT治疗本身和ECT诱导的抗抑郁作用在CSF和血液。
Objectives: Evidence points towards an important relationship between the antidepressant effects of electroconvulsive therapy (ECT) and the modulation of the immune system. To further elucidate this interplay, we performed a study on the effects of the antidepressant treatment by ECT on 25 cytokines in patients with depression.Methods: We measured 25 different cytokines (interleukin (IL)-1β, IL-1RA, Il-2, IL-2R, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p40/p70), IL-13, IL-15, IL-17, tumor necrosis factor-α, interferon (IFN)-α, IFN-γ, granulocyte-macrophage colony-stimulating factor, macrophage inflammatory protein (MIP)-1α, MIP-1β, IFN-γ-induced protein 10 (IP-10), monokine induced by IFN-γ, Eotaxin, Rantes and monocyte chemoattractant protein 1) in the cerebrospinal fluid (CSF) and blood of 12 patients with a severe and treatment-resistant depressive episode before and after a course of ECT.Results: CSF levels of IP-10, IL-5 and IL-8 were elevated after ECT and more ECT sessions were associated with the differences of CSF levels before and after ECT of IFN-γ, IL-2RA, Rantes, IL-6 and IL-1β. Responders and/or remitters had a decrease of CSF levels of IL-17, MIP-1α, Rantes and IL-2R during ECT. CSF IP-10 levels increased less during ECT in patients who had a remission.Conclusions: Although the sample size was small, we found different effects of the ECT treatment per se and of the antidepressant action induced by ECT in CSF and blood.
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影响因子：
6.6
作者：
Fluitman, Sjoerd B. A. H. A.;Heijnen, Cobi J.;Westenberg, Herman G. M.
通讯作者：
Westenberg, Herman G. M.
影响因子：
4.2
作者：
Maier, B;Laurer, HL;Marzi, I
通讯作者：
Marzi, I
影响因子：
6.6
作者：
Rush G;O'Donovan A;Nagle L;Conway C;McCrohan A;O'Farrelly C;Lucey JV;Malone KM
通讯作者：
Malone KM
影响因子：
10.5
作者：
O'Brien, Sinead M.;Scott, Lucinda V.;Dinan, Timothy G.
通讯作者：
Dinan, Timothy G.
影响因子：
9.3
作者：
Bromander S;Anckarsäter R;Kristiansson M;Blennow K;Zetterberg H;Anckarsäter H;Wass CE
通讯作者：
Wass CE