Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu.
Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu.
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DOI：
10.1016/j.ajog.2011.03.039
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发表时间：
2011-07
影响因子：
9.8
通讯作者：
Bodnar LM
中科院分区：
文献类型：
--
作者：
Simhan HN;Himes KP;Venkataramanan R;Bodnar LM
我们以前曾报道过妊娠早期子宫颈抗炎细胞因子升高与自发性早产有关。本研究旨在探讨血清叶酸维生素与下生殖道炎症环境的关系。对妊娠<16周的孕妇（n=417）的血清样品分析叶酸种类（5-甲基四氢叶酸（5 MeTHF）、5-甲酰基四氢叶酸（5 FoTHF）），并测定宫颈液的细胞因子浓度。因子分析确定促炎（PRO）细胞因子（白细胞介素（IL）-1β、IL-6、IL-8、IL-10、单核细胞趋化蛋白-1）和抗炎（ANTI）细胞因子（IL-4、IL-10、IL-13）的模式。调整混杂因素后，母体血清5 MeTHF浓度与ANTI评分升高呈强负相关，而血清5 FoTHF浓度与ANTI评分升高呈正相关（均p<0.05）。母体叶酸与PRO评分无关。母体血清叶酸维生素与宫颈细胞因子浓度相关，提示叶酸与早产风险之间可能存在机械联系。
We previously reported that elevated anti-inflammatory cervical cytokines in early pregnancy were associated with spontaneous preterm birth. Our objective was to explore the relation between serum folate vitamers and the lower genital tract inflammatory milieu. Pregnant women (n=417) at <16 wk gestation had serum samples analyzed for folate species (5-methyltetrahydrofolate (5MeTHF), 5-formyltetrahydrofolate (5FoTHF)) and cervical fluid assayed for cytokine concentrations. Patterns in pro-inflammatory (PRO) cytokines (interleukin (IL)-1β, IL-6, IL-8, IL-10, monocyte chemotactic protein-1) and anti-inflammatory (ANTI) cytokines (IL-4, IL-10, IL-13) were identified with factor analysis. After confounder adjustment, maternal serum 5MeTHF concentrations had a strong, negative association with elevated ANTI scores, while serum 5FoTHF concentrations were positively associated with elevated ANTI scores (both p<0.05). Maternal folate was not associated with PRO scores. Maternal serum folate vitamers are associated with cervical cytokine concentrations, suggesting a possible mechanistic link between folate and preterm birth risk.
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影响因子：
7.1
作者：
Bodnar, Lisa M.;Himes, Katherine P.;Simhan, Hyagriv N.
通讯作者：
Simhan, Hyagriv N.
DOI：
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发表时间：
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