Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study.
Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study.
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DOI：
10.1136/bmj.k4372
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发表时间：
2018-10-31
期刊：
影响因子：
--
通讯作者：
Eisenberg ML
中科院分区：
文献类型：
--
作者：
Khandwala YS;Baker VL;Shaw GM;Stevenson DK;Lu Y;Eisenberg ML
评估美国父亲高龄对孕产妇和围产期结局的影响。回顾性、基于人群的队列研究。我们2007年至2016年期间有40 529 905例活产记录。主要围产期结局包括胎龄、出生体重、5分钟Apgar评分、新生儿重症监护室入院、产后抗生素使用情况和癫痫发作。主要的母体结局是妊娠期糖尿病和先兆子痫。次要结局是可预防的围产期事件的数量。父亲年龄越大，早产、低出生体重和低Apgar评分的风险越高。校正母亲年龄后，与25至34岁的父亲所生的婴儿相比，45岁或以上的父亲所生的婴儿早产的几率高14%（比值比1.14，95%置信区间1.13至1.15），与胎龄无关，癫痫发作的几率高18%（1.18，0.97至1.44）。与年龄最大的伴侣在一起的母亲患妊娠期糖尿病的几率高出34%（1.34，1.29至1.38）。据估计，13.2%（95%置信区间12.5%至13.9%）的早产和18.2%（17.5%至18.9%）的妊娠期糖尿病与高龄父亲有关。父亲高龄对母亲和子女都有负面影响。鉴于美国高龄父亲的患病率相对较低，人口水平的影响目前是适度的。尽管如此，在过去的一代人中，美国的高龄父亲已经翻了一番，因此有必要进一步调查对出生结果和公共卫生的影响。
To evaluate the impact of advanced paternal age on maternal and perinatal outcomes in the United States. Retrospective, population based cohort study. US. 40 529 905 documented live births between 2007 and 2016. Primary perinatal outcomes were gestational age, birth weight, Apgar score at five minutes, admission to a neonatal intensive care unit, need for postpartum antibiotics, and seizures. Primary maternal outcomes were gestational diabetes and pre-eclampsia. Secondary outcome was the number of preventable perinatal events. Higher paternal age was associated with an increased risk of premature birth, low birth weight, and low Apgar score. After adjustment for maternal age, infants born to fathers aged 45 years or older had 14% higher odds of premature birth (odds ratio 1.14, 95% confidence interval 1.13 to 1.15), independent of gestational age, and 18% higher odds of seizures (1.18, 0.97 to 1.44) compared with infants of fathers aged 25 to 34 years. The odds of gestational diabetes was 34% higher (1.34, 1.29 to 1.38) in mothers with the oldest partners. 13.2% (95% confidence interval 12.5% to 13.9%) of premature births and 18.2% (17.5% to 18.9%) of gestational diabetes in births associated with older fathers were estimated to be attributable to advanced paternal age. Advanced paternal age is associated with negative effects on both mothers and offspring. Given the relatively low prevalence of advanced paternal age in the US, population level impacts are currently modest. Nevertheless, as advanced paternal age has doubled in the US over the past generation, further investigation is warranted of the impact on birth outcomes and public health.
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影响因子：
5
作者：
PARKER, JD;SCHOENDORF, KC
通讯作者：
SCHOENDORF, KC
影响因子：
64.8
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2.3
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通讯作者：
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作者：
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通讯作者：
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影响因子：
105.7
作者：
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