Ionic liquid stationary phase coating optimization for semi-packed microfabricated columns.
Ionic liquid stationary phase coating optimization for semi-packed microfabricated columns.
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DOI：
10.1016/j.chroma.2021.462144
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发表时间：
2021-06-21
影响因子：
4.1
通讯作者：
Agah, Masoud
中科院分区：
文献类型：
--
作者：
Gholizadeh, Azam;Chowdhury, Mustahsin;Agah, Masoud
这项工作突出了固定相涂层过程对气相色谱微柱分离效率的影响。用三种不同的双(三氟甲基磺酰)亚胺(NTF2)阴离子液体表征了固定相涂层的质量。含有NTF2阴离子的离子液体因其高温稳定性而被用于气相色谱。在这项工作中，通过分离20种有机成分和饱和烷烃的混合物，评估了柱失活的化学和物理方法以及温度处理。结果表明，烘箱温度越高，处理效率越高，但峰对称性略有下降。在240°C热处理的1-丁基吡啶双(三氟甲基磺酰亚胺)[bpy][NTf2]固定相，对萘的测定高达8300片/米。与200℃处理的色谱柱相比，分离效率提高了5倍，尽管在可接受的范围内，但随着涂层处理温度的提高，尾矿峰值从1.17降至1.46。化学失活和物理失活都提高了分离效率和峰分辨率。
This work highlights the effect of the stationary phase coating process on the separation efficiency of gas chromatography microcolumns. The stationary phase coating quality was characterized by three different bis(trifluoromethylsulfonyl)imide (NTf2) anion based ionic liquids. The ionic liquids containing NTf2 anion are used for gas chromatography due to their high temperature stability. In this work, the chemical and physical approaches of column deactivation as well as the temperature treatment were evaluated by separating a mixture of 20 organic components and saturated alkanes. The results show that higher oven temperature treatment provides higher efficiency while losing a bit of peak symmetry. The thermal treated 1-butylpyridinum bis(trifluoromethylsulfonyl) imide [BPY][NTf2] stationary phase at 240°C demonstrated as high as 8300 plates per meter for naphthalene. This was a 5-fold increase in separation efficiency in comparison to those of the columns treated at 200°C. Albeit being within acceptable ranges, the peak tailing degraded from 1.17 to 1.46 for naphthalene when the processing temperature for coating increased. Both chemical and physical deactivation process increased separation efficiencies and peak resolution.
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