Searching for neuropathology: gliosis in schizophrenia.
Searching for neuropathology: gliosis in schizophrenia.
复制标题
DOI：
10.1016/j.biopsych.2010.08.027
复制
发表时间：
2011-01-15
影响因子：
10.6
通讯作者：
Dwork, Andrew J.
中科院分区：
文献类型：
--
作者：
Schnieder, Tatiana P.;Dwork, Andrew J.
关键词：
The neuropathology of schizophrenia remains elusive. One indication of this elusiveness is that the literature, in contrast to that on the neuropathology of almost any other disease, deals predominantly with measures of normal structures rather than with the demonstration and characterization of pathological structures. An important exception to this trend has been the continued search, over four decades, for reactive glia. In this article, we review histological and radiological evidence for and against astrocytosis and microgliosis specifically associated with schizophrenia. The studies are generally limited by small samples, flawed designs, and potentially biased methods of counting cells. Interpretation of these studies is further complicated by the frequent presence of glial reactions in older individuals without psychiatric disease. Nonetheless, some of the positive findings in the literature cannot easily be dismissed. A sufficiently large autopsy study, weighted towards younger subjects, could provide a definitive answer, which if positive could be a major step towards finding an underlying pathological process.
登录
查看更多内容
影响因子：
6.6
作者：
Dwork, AJ
通讯作者：
Dwork, AJ
影响因子：
2.5
作者：
Bayer, TA;Buslei, R;Falkai, P
通讯作者：
Falkai, P
影响因子：
--
作者：
Arnold, SE;Trojanowski, JQ;Choi, C
通讯作者：
Choi, C
影响因子：
11.2
作者：
DEKOSKY, ST;SCHEFF, SW
通讯作者：
SCHEFF, SW
影响因子：
12.7
作者：
Arnold, SE;Franz, BR;Gur, RE
通讯作者：
Gur, RE