Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling.
Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling.
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DOI：
10.1016/j.neuron.2013.01.006
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发表时间：
2013-03-06
期刊：
影响因子：
16.2
通讯作者：
Richardson WD
中科院分区：
文献类型：
--
作者：
Young KM;Psachoulia K;Tripathi RB;Dunn SJ;Cossell L;Attwell D;Tohyama K;Richardson WD
少突胶质细胞前体（OP）继续增殖并产生髓鞘少突胶质细胞（OL）直至成年。目前尚不清楚成年出生的OL是否包裹先前无髓鞘的轴突或重塑现有的髓鞘。我们量化了成年小鼠中枢神经系统不同区域的OP分裂和OL产生，包括4个月大的视神经，其中几乎所有的轴突都已经有髓鞘。即使在那里，所有的OP分裂和产生新的OL和髓鞘的速度高于可以解释的第一次髓鞘裸露的轴突。我们的结论是，成人出生的OL在视神经参与髓鞘重塑，要么取代OL在服务中死亡或插入现有的髓鞘。后者将预测平均节间长度应随着年龄的增长而减少。与此相一致，我们发现，成年出生的OL制定更短，但更多的节间比OL在出生后早期的生活。成年小鼠中枢神经系统中少突胶质细胞（OL）的定量化和髓鞘的产生即使在几乎所有轴突都已经有髓鞘的视神经中也能产生少突胶质细胞。成年小鼠视神经中的少突胶质细胞似乎参与髓鞘重塑。在这项研究中，Young et al.找到成年少突胶质细胞在视神经中重塑髓鞘的证据。
Oligodendrocyte precursors (OPs) continue to proliferate and generate myelinating oligodendrocytes (OLs) well into adulthood. It is not known whether adult-born OLs ensheath previously unmyelinated axons or remodel existing myelin. We quantified OP division and OL production in different regions of the adult mouse CNS including the 4-month-old optic nerve, in which practically all axons are already myelinated. Even there, all OPs were dividing and generating new OLs and myelin at a rate higher than can be explained by first-time myelination of naked axons. We conclude that adult-born OLs in the optic nerve are engaged in myelin remodeling, either replacing OLs that die in service or intercalating among existing myelin sheaths. The latter would predict that average internode length should decrease with age. Consistent with that, we found that adult-born OLs elaborated much shorter but many more internodes than OLs generated during early postnatal life. ► Quanitification of oligodendrocyte (OL) and myelin production in the adult mouse CNS ► OLs are made even in the optic nerve, where nearly all axons are already myelinated ► Adult-born OLs in the optic nerve appear to engage in myelin remodeling It is not known whether adult-born oligodendrocytes ensheath previously unmyelinated axons or remodel existing myelin. In this study, Young et al. find evidence for myelin remodeling by adult-born oligodendrocytes in the optic nerve.
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影响因子：
16.2
作者：
Kang, Shin H.;Fukaya, Masahiro;Yang, Jason K.;Rothstein, Jeffrey D.;Bergles, Dwight E.
通讯作者：
Bergles, Dwight E.
影响因子：
7.8
作者：
Einheber, S;Zanazzi, G;Ching, W;Scherer, S;Milner, TA;Peles, E;Salzer, JL
通讯作者：
Salzer, JL
影响因子：
9.8
作者：
通讯作者：
--
影响因子：
4.2
作者：
McIver, SR;Lee, CS;Goldberg, MP
通讯作者：
Goldberg, MP
DOI：
10.1007/bf01184071
发表时间：
1994-08-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
BUTT, AM;COLQUHOUN, K;BERRY, M
通讯作者：
BERRY, M