The impact of stressful life events on relapse of generalized anxiety disorder.
The impact of stressful life events on relapse of generalized anxiety disorder.
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DOI：
10.1002/da.20919
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发表时间：
2012-05
影响因子：
7.4
通讯作者：
Keller, Martin B.
中科院分区：
文献类型：
--
作者：
Francis, Jennifer L.;Moitra, Ethan;Dyck, Ingrid;Keller, Martin B.
应激性生活事件（SLEs）与精神疾病的发病有关，但对SLEs对已诊断为焦虑症的个体的影响知之甚少，特别是广泛性焦虑症（GAD），其中对生活事件的担忧是一个定义特征。这项研究探讨了SLE对已经诊断为GAD的成年人复发的影响。数据来自哈佛/布朗焦虑研究项目（HARP），这是一项对目前或过去有焦虑症病史的成年人进行的自然主义纵向研究。112名成年人从GAD发作中康复，27名随后在研究期间复发。通过访谈评估了八类SLE，并将其作为GAD复发的预测因子进行了研究。SLE总数的增加与GAD复发的累积概率较高相关，并且存在非显著统计学趋势，表明特定类别的SLE（包括健康、死亡和家人/朋友/家庭）与GAD复发的概率增加相关。SLE会影响GAD的病程，某些类型的压力源可能比其他压力源更相关。与SLE相关的变化和不确定性可能会加剧现有的担忧倾向，即使是那些已经从GAD中康复的人。
Stressful life events (SLEs) are associated with the onset of psychiatric disorders but little is known about the effects of SLEs on individuals already diagnosed with an anxiety disorder, particularly generalized anxiety disorder (GAD) in which worry about life events is a defining characteristic. This study examined the impact of SLEs on relapse in adults already diagnosed with GAD. Data are obtained from the Harvard/Brown Anxiety Research Project (HARP), a naturalistic longitudinal study of adults with a current or past history of anxiety disorders. One hundred and twelve adults recovered from an episode of GAD and 27 subsequently relapsed during the study. Eight categories of SLEs were assessed via interview and were examined as predictors of GAD relapse. An increased total number of SLEs was associated with a higher cumulative probability of relapse into episode of GAD and there was a nonsignificant statistical trend indicating specific categories of SLEs including health, death, and family/friends/household were related to an increased probability of relapse into episodes of GAD. SLEs impact the course of GAD and certain types of stressors may be more relevant to symptomatology than others. The change and uncertainty associated with SLEs may exacerbate existing worry tendencies even among those who have recovered from GAD.
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影响因子：
1.9
作者：
KELLER, MB;YONKERS, KA;LAVORI, PW
通讯作者：
LAVORI, PW
影响因子：
1.9
作者：
Brantley, PJ;Mehan, DJ;Jones, GN
通讯作者：
Jones, GN
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE
影响因子：
2.8
作者：
Dugas, MJ;Freeston, MH;Ladouceur, R
通讯作者：
Ladouceur, R