The presence of serum anti-Ascaris lumbricoides IgE antibodies and of Trichuris trichiura infection are risk factors for wheezing and/or atopy in preschool-aged Brazilian children.
The presence of serum anti-Ascaris lumbricoides IgE antibodies and of Trichuris trichiura infection are risk factors for wheezing and/or atopy in preschool-aged Brazilian children.
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DOI：
10.1186/1465-9921-11-114
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发表时间：
2010-08-23
影响因子：
5.8
通讯作者：
Barreto ML
中科院分区：
文献类型：
--
作者：
Alcântara-Neves NM;Badaró SJ;dos Santos MC;Pontes-de-Carvalho L;Barreto ML
阐明引发儿童早期短暂性喘息的因素可能是了解哮喘和其他过敏性疾病以后发病机制的重要一步。短暂性喘息主要归因于病毒感染，尽管对空气过敏原和食物过敏原的敏化可能发生在很小的年龄。在发展中国家，肠道蠕虫感染也与过敏或特应性疾病有关。本研究的目的是探讨鞭虫和蛔虫感染与儿童早期喘息和特应性的关系。采用适用于学龄前儿童的葡萄牙语Isaac第一阶段问卷，嵌套在儿童腹泻队列研究中，对682名儿童进行了横断面研究。每名儿童两份粪便样本被检查是否存在肠道蠕虫感染。在这些儿童的一个子样本中，检测了针对三种过敏性制剂(屋尘螨、热带布鲁氏菌和普通儿童食品)的IGE抗体，以及针对伦布氏菌抗原的抗体，这些儿童的父母允许进行这一程序。特应性的定义是存在血清中抗三种过敏原制剂中至少一种的血清≥0.35kU/L抗体水平。毛滴虫活动性感染与儿童喘息呈正相关[调整后OR=2.60；CI=1.54；4.38]，在特应性儿童亚群中[调整后OR=3.07；CI=1.00；9.43]。与特应症的关联也是积极的，只有在蛮力分析中才有统计学意义[OR=2.13；CI=1.03；4.40]。抗A抗体。在特应性儿童[调整OR=2.01；CI=1.00；4.50]和非特应性儿童[调整OR=3.07；CI=1.13；8.35]中，蛔虫IgE抗体与特应性喘息呈正相关，与特应性有关[调整OR=7.29；CI=3.90；13.4]。另一方面，喘息的报道与特应性疾病没有明显的联系。这些数据证实了之前的研究，这些研究表明喘息主要与幼儿感染有关，并表明抗A。蛔虫IgE抗体，而不是活动性蛔虫感染，与喘息和特应性有关。此外，数据表明毛滴虫感染可能在儿童早期特应性喘息的发病机制中发挥作用。
The elucidation of factors that trigger the development of transient wheezing in early childhood may be an important step toward understanding the pathogenesis of asthma and other allergic diseases later in life. Transient wheezing has been mainly attributed to viral infections, although sensitisation to aeroallergens and food allergens may occur at an early age. In developing countries, intestinal helminthic infections have also been associated with allergy or atopy-related disorders. The aim of this study was to explore the association of Trichuris trichiura and Ascaris lumbricoides infections with wheezing and atopy in early childhood. A cross-sectional study using a Portuguese-language ISAAC phase I questionnaire, adapted for preschool-aged children, nested in a cohort study of childhood diarrhoea, was conducted on 682 children. Two faecal samples per child were examined for the presence of intestinal helminthic infection. IgE antibodies against three allergenic preparations (Dermatophagoides pteronyssinus, Blomia tropicalis and common child food), as well as against A. lumbricoides antigens, were measured in a sub-sample of these children, whose parents allowed the procedure. Atopy was defined by the presence of levels of serum IgE antibodies ≥0.35 kU/L against at least one of the three tested allergenic preparations. Active T. trichiura infection but not A. lumbricoides infection was positively associated with wheezing in the total studied children population [adjusted OR = 2.60; CI = 1.54;4.38] and in the atopic children sub-population [adjusted OR = 3.07; CI = 1.00;9.43]. The association with atopy was also positive and statistically significant only in the brute analysis [OR = 2.13; CI = 1.03;4.40]. Anti-A. lumbricoides IgE antibodies, but not current A. lumbricoides infection, were positively associated with wheezing in atopic children [adjusted OR = 2.01; CI = 1.00;4.50] and in non-atopic children [adjusted OR = 3.07; CI = 1.13;8.35] and it was also associated with atopy [adjusted OR = 7.29; CI = 3.90; 13.4]. On the other hands, reports of wheezing were not significantly associated with atopy. These data corroborate previous studies showing that wheezing is predominantly associated with infection in early childhood and shows that anti-A. lumbricoides IgE antibodies, but not active Ascaris infections, are associated with wheezing and atopy. Additionally, the data demonstrate that T. trichiura infection may play a role in the pathogenesis of atopic wheezing in early childhood.
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DOI：
10.1159/000088881
发表时间：
2006-01-01
期刊：
PARASITES AND ALLERGY
影响因子：
--
作者：
Jankovic, Dragana;Steinfelder, Svenja;Sher, Alan
通讯作者：
Sher, Alan
影响因子：
4.4
作者：
Wickman, M;Ahlstedt, S;Hamsten, MV
通讯作者：
Hamsten, MV
影响因子：
14.2
作者：
Hunninghake, Gary M.;Soto-Quiros, Manuel E.;Celedon, Juan C.
通讯作者：
Celedon, Juan C.
影响因子：
5.4
作者：
Genser, Bernd;Strina, Agostino;Barreto, Mauricio L.
通讯作者：
Barreto, Mauricio L.
影响因子：
3.3
作者：
Wordemann, Meike;Diaz, Raquel Junco;Polman, Katja
通讯作者：
Polman, Katja