Prospective Study Examining the Effects of Extreme Drinking on Brain Structure in Emerging Adults.
Prospective Study Examining the Effects of Extreme Drinking on Brain Structure in Emerging Adults.
复制标题
前瞻性研究检查了极端饮酒对新兴成年人大脑结构的影响。
DOI：
10.1111/acer.14446
复制
发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Kerns JG
中科院分区：
文献类型：
--
作者：
Hua JPY;Sher KJ;Boness CL;Trela CJ;McDowell YE;Merrill AM;Piasecki TM;Kerns JG
成年初期是一个关键的神经发育时期，在这个时期，过度饮酒有潜在的明显的神经毒性作用。因此，极度饮酒，即使是一次，也可能对发育中的大脑结构造成特别大的伤害。与此相关的是，初生成人大量饮酒与结构性脑损伤有关，尤其是胼胝体。然而，目前尚不清楚一次极端饮酒是否会影响大脑形态测定学，以及影响程度有多大。在文献中，本研究首次前瞻性地研究了极端饮酒事件（即21岁生日庆祝）对新生成人在生日庆祝后立即（n = 50）和生日庆祝后约五周（n = 29）的大脑形态计量学的影响。我们发现有证据表明，一次极端饮酒与生日庆祝后立即发生的结构变化有关。具体来说，21岁生日时较高的血液酒精浓度（eBAC）与生日后立即减少的后部和中央胼胝体体积有关。21岁生日后5周，这种极端饮酒的情况与进一步的结构变化或恢复无关。总的来说，结果表明，成年初期的一次重度饮酒可能与胼胝体的直接结构变化有关。因此，以酗酒率高为特征的成年初期可能是有针对性的预防和干预的关键时期。
Emerging adulthood is a critical neurodevelopment period in which extreme drinking has a potentially pronounced neurotoxic effect. Therefore, extreme drinking, even a single episode, could be particularly harmful to the developing brain’s structure. Relatedly, heavy alcohol use in emerging adults has been associated with structural brain damage, especially in the corpus callosum. However, it is unclear whether and how much a single extreme drinking episode would affect brain morphometry. For the first time in the literature, the current study prospectively examined the impact of an extreme drinking episode (i.e., 21st birthday celebration) on the brain morphometry of emerging adults immediately following their birthday celebration (n = 50) and approximately five weeks post-birthday celebration (n = 29). We found evidence that a single extreme drinking episode was associated with structural changes immediately post-birthday celebration. Specifically, higher 21st birthday estimated blood-alcohol concentration (eBAC) was associated with decreased volume of the posterior and central corpus callosum immediately post-birthday celebration. This extreme drinking episode was not associated with further structural changes, or recovery, five weeks post-21st birthday celebration. Overall, results suggest that a single episode of heavy drinking in emerging adulthood may be associated with immediate structural changes of the corpus callosum. Thus, emerging adulthood, which is characterized by high rates of extreme drinking, could be a critical period for targeted prevention and intervention.
登录
查看更多内容
影响因子：
2.7
作者：
Benjamini, Yoav;Krieger, Abba M.;Yekutieli, Daniel
通讯作者：
Yekutieli, Daniel
DOI：
10.1523/jneurosci.5122-09.2010
发表时间：
2010-08-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Luders E;Thompson PM;Toga AW
通讯作者：
Toga AW
影响因子：
5.7
作者：
Barnes, Josephine;Ridgway, Gerard R.;Fox, Nick C.
通讯作者：
Fox, Nick C.
影响因子：
7.6
作者：
Chanraud, Sandra;Martelli, Catherine;Martinot, Jean-Luc
通讯作者：
Martinot, Jean-Luc
影响因子：
3.7
作者：
Im, Kiho;Lee, Jong-Min;Kim, Sun I.
通讯作者：
Kim, Sun I.