Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments.
Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments.
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DOI：
10.1155/2011/924045
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发表时间：
2011
影响因子：
2
通讯作者：
Ahrné S
中科院分区：
文献类型：
--
作者：
Håkansson A;Bränning C;Molin G;Adawi D;Hagslätt ML;Nyman M;Jeppsson B;Ahrné S
已知炎症与结直肠癌的发生有关，目的是评估葡聚糖硫酸钠（DSS-）诱导的大鼠循环结肠肿瘤模型（CTM）中的恶性潜能和炎症程度，并将其与氧化偶氮甲烷（AOM-）诱导的CTM模型进行比较。两组均发生肿瘤，但DSS组结肠粘膜出现水肿，出血性糜烂数量和发育异常病变数量较高，髓过氧化物酶粘膜浓度和肠杆菌科粪便活菌计数也较高。肝脏脂肪变性，实质损失，出血和炎症浸润的评估，和较高比例的乙酸和较低比例的丁酸在结肠contents. DSS模型似乎模仿的临床情况，并可能是有价值的调查炎症相关的异型增生和结肠癌，以及改变肝功能的内源性炎症介质。
Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count of Enterobacteriaceae. The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and lower proportions of butyrate in colonic content were found. The DSS model seems to mimic the clinical situation and may be valuable for investigation of inflammation-related dysplasia and colon cancer, as well as for altered liver function by endogenous inflammatory mediators.
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DOI：
10.1124/jpet.103.053595
发表时间：
2003-10-01
影响因子：
3.5
作者：
Kono, H;Asakawa, M;Matsumoto, Y
通讯作者：
Matsumoto, Y
影响因子：
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作者：
ASP, NG;JOHANSSON, CG;SILJESTROM, M
通讯作者：
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影响因子：
4.7
作者：
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通讯作者：
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影响因子：
24.5
作者：
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通讯作者：
MORTENSEN, PB
影响因子：
8.8
作者：
Deutschman, Clifford S.;Cereda, Maurizio;Raj, Nichelle R.
通讯作者：
Raj, Nichelle R.