Current advances in detection and treatment of babesiosis.
Current advances in detection and treatment of babesiosis.
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DOI：
10.2174/092986712799828355
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发表时间：
2012
影响因子：
4.1
通讯作者：
Canto GJ
中科院分区：
文献类型：
--
作者：
Mosqueda J;Olvera-Ramirez A;Aguilar-Tipacamu G;Canto GJ
巴贝斯虫病是一种全球分布的疾病，影响许多哺乳动物物种，主要是牛和人。主要影响发生在养牛业，由于受感染动物的肉类和牛肉生产损失和死亡，牛巴贝斯虫病对养牛业产生了巨大的经济影响。如今，除了这些费用之外，还必须加上蜱虫控制、疾病检测、预防和治疗的高昂费用。自首次报告该疾病以来的近25年里，事实是：没有安全有效的疫苗，化疗选择有限，很少有低成本、可靠和快速的检测方法。巴贝斯虫病的检测和治疗是控制巴贝斯虫病的重要手段。显微镜检测方法仍然是用于鉴定巴贝虫寄生虫的最便宜和最快的方法，尽管它们的敏感性和特异性有限。新的免疫学方法正在开发中，它们提供了比传统方法更快、更敏感和更具体的选择，尽管宿主组织中寄生虫抗原的直接免疫学诊断仍然缺失。基于核酸鉴定及其扩增的检测方法是目前最灵敏、最可靠的技术；重要的是，这些方法大多是在基因组学和生物信息学时代之前开发的，这为优化留下了充足的空间。多年来，巴贝斯虫病的治疗一直基于使用很少的药物，如吡虫威或醋酸咪唑胺。最近，开发和评估了几种药理化合物，为控制疾病提供了新的选择。随着牛巴贝斯虫基因组全序列和双歧巴贝斯虫基因组计划的开展，后基因组时代为巴贝斯虫的诊断方法和新的化疗靶点的发展带来了新的曙光。在这篇综述中，我们将介绍目前在牛和其他动物巴贝斯虫病的检测和治疗方面的进展，并额外提到几种顶复体寄生虫。
Babesiosis is a disease with a world-wide distribution affecting many species of mammals principally cattle and man. The major impact occurs in the cattle industry where bovine babesiosis has had a huge economic effect due to loss of meat and beef production of infected animals and death. Nowadays to those costs there must be added the high cost of tick control, disease detection, prevention and treatment. In almost a century and a quarter since the first report of the disease, the truth is: there is no a safe and efficient vaccine available, there are limited chemotherapeutic choices and few low-cost, reliable and fast detection methods. Detection and treatment of babesiosis are important tools to control babesiosis. Microscopy detection methods are still the cheapest and fastest methods used to identify Babesia parasites although their sensitivity and specificity are limited. Newer immunological methods are being developed and they offer faster, more sensitive and more specific options to conventional methods, although the direct immunological diagnoses of parasite antigens in host tissues are still missing. Detection methods based on nucleic acid identification and their amplification are the most sensitive and reliable techniques available today; importantly, most of those methodologies were developed before the genomics and bioinformatics era, which leaves ample room for optimization. For years, babesiosis treatment has been based on the use of very few drugs like imidocarb or diminazene aceturate. Recently, several pharmacological compounds were developed and evaluated, offering new options to control the disease. With the complete sequence of the Babesia bovis genome and the B. bigemina genome project in progress, the post-genomic era brings a new light on the development of diagnosis methods and new chemotherapy targets. In this review, we will present the current advances in detection and treatment of babesiosis in cattle and other animals, with additional reference to several apicomplexan parasites.
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影响因子：
4
作者：
Böse R;Peymann B
通讯作者：
Peymann B
影响因子：
2
作者：
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通讯作者：
Wright IG
DOI：
10.4269/ajtmh.1985.34.45
发表时间：
1985-01-01
影响因子：
3.3
作者：
AIKAWA, M;RABBEGE, J;MILLER, LH
通讯作者：
MILLER, LH
影响因子：
2.6
作者：
Alhassan, Andy;Thekisoe, Oriel M. M.;Igarashi, Ikuo
通讯作者：
Igarashi, Ikuo
影响因子：
4.9
作者：
Arruda, DC;D'Alexandri, FL;Uliana, SRB
通讯作者：
Uliana, SRB