Repurposing Plant Virus Nanoparticles.

Repurposing Plant Virus Nanoparticles.
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DOI:
10.3390/vaccines6010011
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发表时间:
2018-02-14
期刊:
影响因子:
7.8
通讯作者:
Hefferon KL
Hefferon KL
中科院分区:
医学3区
文献类型:
--
作者:
Hefferon KL

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多年来,人们一直在探索植物作为生产疫苗和其他生物药物的廉价和多功能平台。植物病毒也被改造成表达亚单位疫苗或充当表位呈递系统。二十面体病毒和螺旋状的植物病毒都被用于这些目的。最近,植物病毒已被用作纳米颗粒,将药物和活性分子运送到癌细胞中。以下综述描述了二十面体和螺旋植物病毒在各种抗癌新功能中的应用。该综述说明了不同植物病毒纳米颗粒之间的变化幅度以及这如何影响免疫反应。
Plants have been explored for many years as inexpensive and versatile platforms for the generation of vaccines and other biopharmaceuticals. Plant viruses have also been engineered to either express subunit vaccines or act as epitope presentation systems. Both icosahedral and helical, filamentous-shaped plant viruses have been used for these purposes. More recently, plant viruses have been utilized as nanoparticles to transport drugs and active molecules into cancer cells. The following review describes the use of both icosahedral and helical plant viruses in a variety of new functions against cancer. The review illustrates the breadth of variation among different plant virus nanoparticles and how this impacts the immune response.
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