Nanoparticles for biomedical imaging.
Nanoparticles for biomedical imaging.
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DOI：
10.1517/17425240903229031
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发表时间：
2009-11
影响因子：
6.6
通讯作者：
Berkland CJ
中科院分区：
文献类型：
--
作者：
Nune SK;Gunda P;Thallapally PK;Lin YY;Forrest ML;Berkland CJ
合成纳米粒子正在成为生物医学应用中的通用工具，特别是在生物医学成像领域。直径为1 - 100 nm的纳米颗粒具有与生物功能单元相当的尺寸。不同的表面化学，独特的磁性，可调的吸收和发射特性，以及各种纳米粒子的合成和工程的最新进展表明它们作为早期检测疾病（如癌症）的探针的潜力。表面功能化进一步扩大了纳米粒子作为分子成像探针的潜力。总结纳米颗粒用于生物医学成像的新兴研究，其具有增加的选择性和减少的非特异性摄取，以及增加的空间分辨率，含有与靶向配体缀合的稳定剂。本文综述了近年来各种纳米粒子探针的合成技术进展，并探讨了提高纳米粒子靶向的方法，以促进其在生物医学成像中的应用。用于生物医学成像的纳米材料的结构设计继续扩大和多样化。合成方法旨在控制纳米颗粒的尺寸和表面特性，以控制分布、半衰期和消除。尽管使用纳米颗粒的分子成像应用正在进入临床应用，但仍应继续解决储存稳定性和长期毒理学等挑战。
Synthetic nanoparticles are emerging as versatile tools in biomedical applications, particularly in the area of biomedical imaging. Nanoparticles 1 – 100 nm in diameter have dimensions comparable to biological functional units. Diverse surface chemistries, unique magnetic properties, tunable absorption and emission properties, and recent advances in the synthesis and engineering of various nanoparticles suggest their potential as probes for early detection of diseases such as cancer. Surface functionalization has expanded further the potential of nanoparticles as probes for molecular imaging. To summarize emerging research of nanoparticles for biomedical imaging with increased selectivity and reduced nonspecific uptake with increased spatial resolution containing stabilizers conjugated with targeting ligands. This review summarizes recent technological advances in the synthesis of various nanoparticle probes, and surveys methods to improve the targeting of nanoparticles for their application in biomedical imaging. Structural design of nanomaterials for biomedical imaging continues to expand and diversify. Synthetic methods have aimed to control the size and surface characteristics of nanoparticles to control distribution, half-life and elimination. Although molecular imaging applications using nanoparticles are advancing into clinical applications, challenges such as storage stability and long-term toxicology should continue to be addressed.
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影响因子：
17.1
作者：
Anderson, Robin E.;Chan, Warren C. W.
通讯作者：
Chan, Warren C. W.
DOI：
10.1073/pnas.152463399
发表时间：
2002-10-01
影响因子：
11.1
作者：
Åkerman, ME;Chan, WCW;Ruoslahti, E
通讯作者：
Ruoslahti, E
影响因子：
3.8
作者：
Clift, Martin J. D.;Rothen-Rutishauser, Barbara;Stone, Vicki
通讯作者：
Stone, Vicki
影响因子：
13.3
作者：
Bailey, Mark M.;Berkland, Cory J.
通讯作者：
Berkland, Cory J.
影响因子：
46.9
作者：
Ahrens, ET;Flores, R;Morel, PA
通讯作者：
Morel, PA