Superparamagnetic iron oxide nanoparticle-based delivery systems for biotherapeutics.
Superparamagnetic iron oxide nanoparticle-based delivery systems for biotherapeutics.
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DOI：
10.1517/17425247.2013.747507
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发表时间：
2013-01
影响因子：
6.6
通讯作者：
Zhang M
中科院分区：
文献类型：
--
作者：
Mok H;Zhang M
基于超顺磁性氧化铁纳米粒子（SPION）的载流子体系比其他基于纳米粒子的体系具有许多优点。它们具有生物相容性、可生物降解性、易于调节和超顺磁性，因此可以通过外部磁场控制。这些特性使其具有广泛的生物医学应用。特别是，磁驱动载体由于其优越的递送效率，作为一种新兴的治疗递送系统引起了相当大的兴趣。本文综述了近年来基于spion的载体系统在提高生物治疗药物的递送效率和靶向特异性方面的研究进展。我们研究了各种基于SPION的递送系统的配方，包括SPION胶束、团簇、水凝胶、脂质体和微/纳米球，以及它们在生物治疗药物递送中的特定应用。最近，包括治疗细胞、蛋白质和基因在内的生物疗法已被研究作为各种疾病的替代疗法。尽管生物治疗药物具有靶向特异性高、不良反应低的优势，但与化学药物相比，稳定性差、递送效率低一直阻碍着生物治疗药物的临床转译。因此，可以克服这些限制的生物治疗递送系统正在积极寻求。由于其优异的生物相容性和超顺磁性，利用合适的磁铁可以在目标部位长期积累/保留，因此基于spion的材料可以成为开发此类递送系统的理想候选者。此外，精细调谐、均相SPIONs的合成技术也得到了很好的发展，这可能保证它们的快速临床转化。
Superparamagnetic iron oxide nanoparticle (SPION)-based carrier systems have many advantages over other nanoparticle-based systems. They are biocompatible, biodegradable, facilely tunable, and superparamagnetic and thus controllable by an external magnetic field. These attributes enable their broad biomedical applications. In particular, magnetically-driven carriers are drawing considerable interest as an emerging therapeutic delivery system because of their superior delivery efficiency. This article reviews the recent advances in use of SPION-based carrier systems to improve the delivery efficiency and target specificity of biotherapeutics. We examine various formulations of SPION-based delivery systems, including SPION micelles, clusters, hydrogels, liposomes, and micro/nanospheres, as well as their specific applications in delivery of biotherapeutics. Recently, biotherapeutics including therapeutic cells, proteins and genes have been studied as alternative treatments to various diseases. Despite the advantages of high target specificity and low adverse effects, clinical translation of biotherapeutics has been hindered by the poor stability and low delivery efficiency compared to chemical drugs. Accordingly, biotherapeutic delivery systems that can overcome these limitations are actively pursued. SPION-based materials can be ideal candidates for developing such delivery systems because of their excellent biocompatibility and superparamagnetism that enables long-term accumulation/retention at target sites by utilization of a suitable magnet. In addition, synthesis technologies for production of finely-tuned, homogeneous SPIONs have been well developed, which may promise their rapid clinical translation.
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影响因子：
3.7
作者：
Chorny, Michael;Alferiev, Ivan S.;Fishbein, Ilia;Tengood, Jillian E.;Folchman-Wagner, Zoe;Forbes, Scott P.;Levy, Robert J.
通讯作者：
Levy, Robert J.
影响因子：
38.3
作者：
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通讯作者：
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影响因子：
16.6
作者：
Ge, Jianping;Hu, Yongxing;Yin, Yadong
通讯作者：
Yin, Yadong
影响因子：
13.3
作者：
Fang, Chen;Bhattarai, Narayan;Sun, Conroy;Zhang, Miqin
通讯作者：
Zhang, Miqin
影响因子：
2.9
作者：
Deddens, Lisette H.;Van Tilborg, Geralda A. F.;Dijkhuizen, Rick M.
通讯作者：
Dijkhuizen, Rick M.