A distinct molecular profile associated with mucinous epithelial ovarian cancer.
A distinct molecular profile associated with mucinous epithelial ovarian cancer.
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DOI：
10.1038/sj.bjc.6603003
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发表时间：
2006-03-27
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
粘液性上皮性卵巢癌（MOC）在临床和形态学上与卵巢癌的其他组织学亚型不同。为了确定 MOC 的遗传基础并鉴定潜在的肿瘤标志物，使用包含 > 59000 个探针组的定制寡核苷酸微阵列对 49 种不同组织学亚型的原发性卵巢癌进行了基因表达谱分析。结果表明，MOC 表达的基因谱与上皮性卵巢癌的其他亚型既不同又重叠。与其组织学表型一致，MOC 表达不同上皮来源的粘液癌（包括肠癌）的特征基因。通过 RT-PCR 和/或免疫组织化学证实了 MOC 与卵巢癌其他组织学亚型之间基因表达的差异。特别是，半乳糖凝集素 4 (LGALS4) 在 MOC 中高度特异性表达，但在良性粘液囊肿和交界性（非典型增殖性）肿瘤中表达水平较低，支持 MOC 的恶性进展模型。因此，LGALS4 可能作为 MOC 的早期和鉴别诊断标记物具有应用价值。
Mucinous epithelial ovarian cancers (MOC) are clinically and morphologically distinct from the other histological subtypes of ovarian cancer. To determine the genetic basis of MOC and to identify potential tumour markers, gene expression profiling of 49 primary ovarian cancers of different histological subtypes was performed using a customised oligonucleotide microarray containing >59 000 probesets. The results show that MOC express a genetic profile that both differs and overlaps with other subtypes of epithelial ovarian cancer. Concordant with its histological phenotype, MOC express genes characteristic of mucinous carcinomas of varying epithelial origin, including intestinal carcinomas. Differences in gene expression between MOC and other histological subtypes of ovarian cancer were confirmed by RT–PCR and/or immunohistochemistry. In particular, galectin 4 (LGALS4) was highly and specifically expressed in MOC, but expressed at lower levels in benign mucinous cysts and borderline (atypical proliferative) tumours, supporting a malignant progression model of MOC. Hence LGALS4 may have application as an early and differential diagnostic marker of MOC.
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影响因子：
29.4
作者：
Hinoi, T;Lucas, PC;Fearon, ER
通讯作者：
Fearon, ER
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Di Renzo, MF
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通讯作者：
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作者：
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通讯作者：
Crompton, MR