Proteomic exploration of common pathophysiological pathways in diabetes and cardiovascular disease.
Proteomic exploration of common pathophysiological pathways in diabetes and cardiovascular disease.
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DOI：
10.1002/ehf2.13036
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发表时间：
2020-12
影响因子：
3.8
通讯作者：
Magnusson M
中科院分区：
文献类型：
--
作者：
Molvin J;Jujić A;Melander O;Pareek M;Råstam L;Lindblad U;Daka B;Leósdóttir M;Nilsson PM;Olsen MH;Magnusson M
The epidemiological association between diabetes and cardiovascular disease is well established, but the pathophysiological link is complex and multifactorial. We investigated seven proteins, previously linked to incident diabetes mellitus, and their association with cardiovascular disease and mortality. Plasma samples from 1713 individuals from the Swedish population‐based Malmö Preventive Project (mean age 67.4 ± 6.0 years; 29.1% women) were analysed with a proximity extension assay panel. Seven proteins [scavenger receptor cysteine rich type 1 protein M130 (CD163), fatty acid‐binding protein 4 (FABP4), plasminogen activator inhibitor 1 (PAI), insulin‐like growth factor‐binding protein 2 (IGFB2), cathepsin D (CTSD), galectin‐4 (GAL4), and paraoxonase‐3 (PON3)] previously shown to be associated with incident diabetes were analysed for associations with all‐cause mortality (ACM), cardiovascular mortality (CVM), incident coronary events (CEs), and incident heart failure (HF). After exclusion of prevalent cases of respective outcome, proteins that met Bonferroni‐corrected significance were analysed in multivariable Cox regression models. Significant associations were identified between five proteins [GAL4 (hazard ratio; 95% confidence interval: 1.17–1.41), CTSD (1.15–1.37), CD163 (1.09–1.30), IGFBP2 (1.05–1.30), and FABP4 (1.04–1.29)] and ACM and four proteins [GAL4 (1.38–1.56), CTSD (1.14–1.43), CD163 (1.09–1.36), and IGFBP2 (1.03–1.35)] with CVM. Three proteins [GAL4 (1.14–1.57), CTSD (1.12–1.50), and FABP4 (1.05–1.55)] were significantly associated with incident CE and two [GAL4 (1.03–1.54) and CTSD (1.01–1.46)] were associated with incident HF after adjusting for traditional risk factors including N‐terminal pro‐brain natriuretic peptide. In a general Swedish population, four proteins previously shown to be associated with diabetes were associated with ACM and CVM. Three proteins were associated with incident CE. Finally, GAL4 and CTSD displayed novel associations with incident HF and were the only proteins associated with all outcomes.
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影响因子：
9.3
作者：
Moller, Holger J.;Frikke-Schmidt, Ruth;Tybjaerg-Hansen, Anne
通讯作者：
Tybjaerg-Hansen, Anne
DOI：
10.1056/nejmoa1603827
发表时间：
2016-07-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Marso SP;Daniels GH;Brown-Frandsen K;Kristensen P;Mann JF;Nauck MA;Nissen SE;Pocock S;Poulter NR;Ravn LS;Steinberg WM;Stockner M;Zinman B;Bergenstal RM;Buse JB;LEADER Steering Committee;LEADER Trial Investigators
通讯作者：
LEADER Trial Investigators
影响因子：
3
作者：
Huflejt, ME;Leffler, H
通讯作者：
Leffler, H
影响因子：
16.2
作者：
Dagenais, G. R.;Gerstein, H. C.;Yusuf, S.
通讯作者：
Yusuf, S.
影响因子：
4.6
作者：
Molvin, John;Pareek, Manan;Magnusson, Martin
通讯作者：
Magnusson, Martin