Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase.
Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase.
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DOI：
10.1016/j.abb.2012.02.016
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发表时间：
2012-07-01
影响因子：
3.9
通讯作者：
Hewison, M.
中科院分区：
文献类型：
--
作者：
Adams, J. S.;Hewison, M.
与维生素 D 受体 (VDR) 一样，CYP27B1 羟化酶在人体组织中广泛表达。该表达谱确定了 VDR 与 CYP27B1、1,25-二羟基维生素 D (1,25-(OH)2D) 产物以内分泌或旁分泌模式相互作用的潜力。这种广泛的表达谱还表明，1,25-(OH)2D 的局部产生和调节 VDR 介导的基因表达的作用可能同样广泛，并且与肾脏中发生的情况不同。近端肾小管上皮细胞是 CYP27B1 最丰富的来源，也是产生 1,25-(OH)2D 的位点，1,25-(OH)2D 注定会起到激素的作用。 CYP27B1 在肾外部位的存在已被广泛记录，尽管该酶在这些组织中的功能影响尚未得到充分证明。两个值得注意的例外是疾病激活的巨噬细胞（例如结节病或结核病）和胎盘。这两种组织能够产生足够的 1,25-(OH)2D，以便在全身循环中可检测到。因此，本综述将仅关注这两个位点的 CYP27B1 表达，理论上这些位点的 1,25-(OH)2D 产生是为了局部免疫调节功能，而不是为了控制宿主或胎儿的钙平衡。
Like the vitamin D receptor (VDR), the CYP27B1-hydroxylase is expressed widely in human tissues. This expression profile establishes the potential for interaction of the VDR with the product of the CYP27B1, 1,25-dihydroxyvitamin D (1,25-(OH)2D), in either an intracrine or paracrine mode. This expansive expression profile also suggests that the local production and action of 1,25-(OH)2D to regulate VDR-directed gene expression may be similarly wide-ranging and distinct from what occurs in the kidney; the proximal renal tubular epithelial cell is the richest source of the CYP27B1 and the site for production of 1,25-(OH)2D destined to function as a hormone. Existence of the CYP27B1 at extrarenal sites has been widely documented, although the functional impact of the enzyme in these tissues has yet to be fully demonstrated. Two notable exceptions are the disease-activated macrophage (e.g., in sarcoidosis or tuberculosis) and the placenta. These two tissues are capable of generating enough 1,25-(OH)2D so as to be detectable in the general circulation. As such, this review will focus on CYP27B1 expression only at these two sites, theorizing that 1,25-(OH)2D production at these sites is for the purpose of local immunoregulatory function, not for controlling calcium balance in the host or the fetus.
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影响因子：
17.1
作者：
Fabri M;Stenger S;Shin DM;Yuk JM;Liu PT;Realegeno S;Lee HM;Krutzik SR;Schenk M;Sieling PA;Teles R;Montoya D;Iyer SS;Bruns H;Lewinsohn DM;Hollis BW;Hewison M;Adams JS;Steinmeyer A;Zügel U;Cheng G;Jo EK;Bloom BR;Modlin RL
通讯作者：
Modlin RL
影响因子：
7.1
作者：
CROSS, NA;HILLMAN, LS;VIEIRA, NE
通讯作者：
VIEIRA, NE
影响因子：
4.1
作者：
Atkins, Gerald J.;Anderson, Paul H.;Morris, Howard A.
通讯作者：
Morris, Howard A.
影响因子：
158.5
作者：
BARBOUR, GL;COBURN, JW;HORST, RL
通讯作者：
HORST, RL
影响因子：
6.5
作者：
Bikle, DD;Chang, S;Elias, PM
通讯作者：
Elias, PM