PhysioZoo: A Novel Open Access Platform for Heart Rate Variability Analysis of Mammalian Electrocardiographic Data.
PhysioZoo: A Novel Open Access Platform for Heart Rate Variability Analysis of Mammalian Electrocardiographic Data.
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PhysioZoo： 哺乳动物心电图数据心率变异性分析的新型开放存取平台。
DOI：
10.3389/fphys.2018.01390
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发表时间：
2018
影响因子：
4
通讯作者：
Yaniv Y
中科院分区：
文献类型：
--
作者：
Behar JA;Rosenberg AA;Weiser-Bitoun I;Shemla O;Alexandrovich A;Konyukhov E;Yaniv Y
背景：连续心跳之间的时间变化通常被称为心率变异性(HRV)。心率变异性复杂性的丧失已经在几种心血管疾病中被记录在案，并且与发病率和死亡率的增加有关。然而，控制心率变异性的机制还不是很清楚。动物实验是研究这一问题的关键。然而，到目前为止，还没有标准的开源工具来分析哺乳动物的心电数据，也没有集中化的公共数据库供研究人员访问。方法：我们创建了一个开源软件解决方案，专门用于从包括人类在内的多种哺乳动物的心电数据中进行心率变异性分析。我们还创建了一套哺乳动物心电信号(狗、兔和老鼠)的公共数据库，其中包含手动校正的R峰(>；170,000个注释)和信号质量注释。这个平台(软件和数据库)被称为PhysioZoo。结果：PhysioZoo可以加载心电数据并执行非常准确的R峰检测(F1>；98%)。它还允许用户手动校正R峰位置，并注释潜在心电的低信号质量。PhysioZoo实施了适用于不同哺乳动物(狗、兔子和老鼠)的最先进的HRV测量方法，并允许轻松导出所有计算的测量方法以及标准数据表示图。PhysioZoo提供了所有HRV测量的数据库和标准范围，这些测量是在健康、清醒的人类、狗、兔子和老鼠休息时计算得出的。对不同哺乳动物的这些测量方法的研究可以为跨物种心率动力学的复杂性提供新的见解。结论：PhysioZoo通过其开放源代码、免费提供的软件和开放获取的数据库，使哺乳动物模型的心率变异分析标准化和重复性。PhysioZoo将支持并支持哺乳动物心率变异性研究的新研究。源代码和软件可在www.Physioo.com上找到。
Background: The time variation between consecutive heartbeats is commonly referred to as heart rate variability (HRV). Loss of complexity in HRV has been documented in several cardiovascular diseases and has been associated with an increase in morbidity and mortality. However, the mechanisms that control HRV are not well understood. Animal experiments are the key to investigating this question. However, to date, there are no standard open source tools for HRV analysis of mammalian electrocardiogram (ECG) data and no centralized public databases for researchers to access. Methods: We created an open source software solution specifically designed for HRV analysis from ECG data of multiple mammals, including humans. We also created a set of public databases of mammalian ECG signals (dog, rabbit and mouse) with manually corrected R-peaks (>170,000 annotations) and signal quality annotations. The platform (software and databases) is called PhysioZoo. Results: PhysioZoo makes it possible to load ECG data and perform very accurate R-peak detection (F1 > 98%). It also allows the user to manually correct the R-peak locations and annotate low signal quality of the underlying ECG. PhysioZoo implements state of the art HRV measures adapted for different mammals (dogs, rabbits, and mice) and allows easy export of all computed measures together with standard data representation figures. PhysioZoo provides databases and standard ranges for all HRV measures computed on healthy, conscious humans, dogs, rabbits, and mice at rest. Study of these measures across different mammals can provide new insights into the complexity of heart rate dynamics across species. Conclusion: PhysioZoo enables the standardization and reproducibility of HRV analysis in mammalian models through its open source code, freely available software, and open access databases. PhysioZoo will support and enable new investigations in mammalian HRV research. The source code and software are available on www.physiozoo.com.
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影响因子：
0.5
作者：
Cintra, Priscila Pavini;Nishimori Duque, Celina Tie;de Mattos Junior, Ewaldo
通讯作者：
de Mattos Junior, Ewaldo
影响因子：
2.4
作者：
Hanton, G;Rabernampianina, Y
通讯作者：
Rabernampianina, Y
影响因子：
56.9
作者：
AKSELROD, S;GORDON, D;COHEN, RJ
通讯作者：
COHEN, RJ
影响因子：
4
作者：
Billman GE
通讯作者：
Billman GE
DOI：
10.1111/j.1471-0528.1984.tb04844.x
发表时间：
1984-01-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
HENSON, G;DAWES, GS;REDMAN, CWG
通讯作者：
REDMAN, CWG