U-shaped association between prevalence of secondary hypogonadism and body mass index: a retrospective analysis of men with testosterone deficiency.
U-shaped association between prevalence of secondary hypogonadism and body mass index: a retrospective analysis of men with testosterone deficiency.
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DOI：
10.1038/s41443-022-00533-z
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发表时间：
2023-06
影响因子：
2.6
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中科院分区：
文献类型：
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在过去的二十年里，美国肥胖症和性腺功能减退症的患病率都有所增加。虽然先前的研究已经表明肥胖和继发性性腺功能减退症（低睾酮和促黄体生成激素）之间存在关联，但很少有人使用足够大的样本量来确定每个体重指数类别的患病率。我们的目的是通过构建一个回顾性数据库，比较体重指数类别之间继发性性腺功能减退症的发生率，这些数据库包含2011年至2020年期间在三级学术医疗中心的泌尿外科诊所就诊期间测量的体重指数，早晨睾酮和黄体生成素水平的男性。既往接受睾酮替代疗法、克罗米芬或阿那曲唑的男性被排除在外。在“R”中进行卡方分析。我们发现，在7211名男性研究中，45.7%，22.6%和4.4%分别被归类为继发性，原发性和代偿性性腺功能减退症的诊断。我们发现，与BMI正常的男性相比，肥胖男性和体重过轻的男性继发性性腺功能减退的患病率增加。这些研究结果支持需要常规筛查标准和个性化的建议，患者处理继发性性腺功能减退症。
The prevalence of both obesity and hypogonadism in the United States has increased over the past two decades. While prior studies have shown an association between obesity and secondary hypogonadism—low testosterone and luteinizing hormone—few have used a large enough sample size to determine prevalence at each body mass index class. We aimed to compare rates of secondary hypogonadism among body mass index classes by constructing a retrospective database with men who had their body mass index, morning testosterone and luteinizing hormone levels measured during a visit to a urology clinic at a tertiary academic medical center between 2011–2020. Men previously on testosterone replacement therapy, Clomiphene, or Anastrozole were excluded. Chi-squared analysis was conducted in “R”. We found that among the 7 211 men studied, 45.7%, 22.6%, and 4.4% were classified as having diagnosis of secondary, primary, and compensated hypogonadism, respectively. We found that obese men and underweight men had increased prevalence of secondary hypogonadism as compared to men with normal BMI. These findings support the need for routine screening criteria and personalized advice to patients dealing with secondary hypogonadism.
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