Androgens and adipose tissue in males: a complex and reciprocal interplay.
Androgens and adipose tissue in males: a complex and reciprocal interplay.
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DOI：
10.1155/2012/789653
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发表时间：
2012
影响因子：
2.8
通讯作者：
Fabbri A
中科院分区：
文献类型：
--
作者：
Mammi C;Calanchini M;Antelmi A;Cinti F;Rosano GM;Lenzi A;Caprio M;Fabbri A
临床证据表明，男性肥胖通常与性腺功能减退有关，反之亦然；此外，低睾丸激素水平被认为是男性代谢综合征的“标志”。这些观察结果表明，在解剖学上和功能上不同的细胞类型（如白色脂肪细胞和间质细胞）之间存在着严格的联系，它们合成睾丸激素。脂肪组织通过其在血液中分泌的产物能够控制睾丸的几种功能。另一方面，循环睾酮和雌二醇水平深刻影响脂肪细胞的增殖、分化和脂肪量分布，从而控制关键的代谢功能，如食物摄入、胰岛素敏感性、血管反应性和免疫力。本文重点介绍了雄激素与脂肪组织之间联系的现有临床和实验证据，并说明了当脂肪质量分布和性腺功能之间的平衡失去时发生的后果。
Clinical evidence shows that in males obesity is frequently associated with hypogonadism and vice versa; also, low testosterone levels have been considered a “hallmark” of metabolic syndrome in men. These observations indicate that there is a strict connection between anatomically and functionally distinct cell types such as white adipocytes and Leydig cells, that synthesize testosterone. Adipose tissue is able to control several functions of the testis through its products secreted in the bloodstream. On the other hand, circulating levels of testosterone and estradiol deeply affect adipocyte proliferation, differentiation, and fat mass distribution, hereby controlling critical metabolic functions, such as food intake, insulin sensitivity, vascular reactivity, and immunity. This paper highlights the existing clinical and experimental evidence linking androgens and adipose tissue and illustrates the consequences occurring when the balance between fat mass distribution and eugonadism is lost.
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影响因子：
6.9
作者：
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通讯作者：
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