Plasma vitamin D and risk of colorectal cancer: the Japan Public Health Center-Based Prospective Study.
Plasma vitamin D and risk of colorectal cancer: the Japan Public Health Center-Based Prospective Study.
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DOI：
10.1038/sj.bjc.6603892
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发表时间：
2007-08-06
影响因子：
8.8
通讯作者：
Tsugane, S.
中科院分区：
文献类型：
--
作者：
Otani, T.;Iwasaki, M.;Sasazuki, S.;Inoue, M.;Tsugane, S.
我们通过日本公共卫生中心前瞻性研究中的嵌套式病例对照研究，调查了血浆25(OH)D与随后的结直肠癌发病风险的关系，该研究覆盖了38名 研究受试者中的375例新诊断的结直肠癌病例，在采血后的11.5年随访期内。每个病例在性别、年龄、研究区域、抽血日期和禁食时间上匹配两个对照组。在调整了吸烟、饮酒、体重指数、体育锻炼、维生素补充剂使用和结直肠癌家族史的配对条件Logistic回归模型中，血浆25(OH)D与男性和女性的结直肠癌没有显著关联。然而，与其他四分位数的组合类别相比，血浆25(OH)D水平最低的类别与男性(优势比(OR)4.6；95%可信区间(CI)1.0-20)和女性(OR，2.7，95%CI，0.94-7.6)的直肠癌风险增加有关。我们的结果提示，低水平的血浆25(OH)D可能会增加直肠癌的风险。
We investigated the association between plasma 25(OH)D and the subsequent colorectal cancer incidence risk by a nested case–control study in The Japan Public Health Center-based Prospective Study, covering 375 newly diagnosed cases of colorectal cancer from 38 373 study subjects during a 11.5-year follow-up after blood collection. Two controls were matched per case on sex, age, study area, date of blood draw, and fasting time. In a conditional logistic regression model with matched pairs adjusted for smoking, alcohol consumption, body mass index, physical exercise, vitamin supplement use, and family history of colorectal cancer, plasma 25(OH)D was not significantly associated with colorectal cancer in men or in women. However, the lowest category of plasma 25(OH)D was associated with an elevated risk of rectal cancer in both men (odds ratio (OR), 4.6; 95% confidence interval (CI), 1.0–20) and women (OR, 2.7, 95% CI, 0.94–7.6), compared with the combined category of the other quartiles. Our results suggest that a low level of plasma 25(OH)D may increase the risk of rectal cancer.
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影响因子：
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