Adrenergic stimulation promotes T-wave alternans and arrhythmia inducibility in a TNF-alpha genetic mouse model of congestive heart failure.
Adrenergic stimulation promotes T-wave alternans and arrhythmia inducibility in a TNF-alpha genetic mouse model of congestive heart failure.
复制标题
在充血性心力衰竭的 TNF-α 遗传小鼠模型中，肾上腺素能刺激可促进 T 波交替和心律失常诱导。
DOI：
10.1152/ajpheart.01024.2008
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
London,Barry
中科院分区：
文献类型：
--
作者：
Shusterman,Vladimir;McTiernan,CharlesF;Goldberg,Anna;Saba,Samir;Salama,Guy;London,Barry
T-wave alternans (TWA) is a proarrhythmic repolarization instability that is common in congestive heart failure (CHF). Although transgenic mice are commonly used to study the mechanisms of arrhythmogenesis in CHF, little is known about the dynamics of TWA in these species. We hypothesized that TWA is present in a TNF-α model of CHF and can be further promoted by adrenergic stimulation. We studied 16 TNF-α mice and 12 FVB controls using1) in vivo intracardiac electrophysiological testing and2) ambulatory telemetry during 30 min before and after an intraperitoneal injection of isoproterenol. TWA was examined using both linear and nonlinear filtering applied in the time domain. In addition, changes in the mean amplitude of the T wave and area under the T wave were computed. During intracardiac electrophysiological testing, none of the animals had TWA or inducible arrhythmias before the injection of isoproterenol. After the injection, sustained TWA and inducible ventricular tachyarrhythmias were observed in TNF-α mice but not in FVB mice. In ambulatory telemetry, before the isoproterenol injection, the cardiac cycle length (CL) was longer in TNF-α mice than in FVB mice (98 ± 9 and 88 ± 3 ms,P= 0.04). After the injection of isoproterenol, the CL became 8% and 6% shorter in TNF-α and FVB mice (P< 10−4); however, the 2% difference between the groups in the magnitude of CL changes was not significant. In TNF-α mice, the magnitude of TWA was 1.5–2 times greater than in FVB mice both before and after the isoproterenol injection. The magnitude of TWA increased significantly after the isoproterenol injection compared with the baseline in TNF-α mice (P= 0.003) but not in FVB mice. The mean amplitude of the T wave and area under the T wave increased 60% and 80% in FVB mice (P= 0.006 and 0.009) but not in TNF-α mice. In conclusion, TWA is present in a TNF-α model of CHF and can be further promoted by adrenergic stimulation, along with the enhanced susceptibility for ventricular arrhythmias.
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DOI：
10.1103/physreve.62.4043
发表时间：
2000-09
期刊：
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics
影响因子：
--
作者：
H. Hastings;F. Fenton;S. Evans;O. Hotomaroglu;J. Geetha;K. Gittelson;J. Nilson;A. Garfinkel
通讯作者：
H. Hastings;F. Fenton;S. Evans;O. Hotomaroglu;J. Geetha;K. Gittelson;J. Nilson;A. Garfinkel
影响因子：
158.5
作者：
ROSENBAUM, DS;JACKSON, LE;COHEN, RJ
通讯作者：
COHEN, RJ
影响因子：
5.5
作者：
Piccirillo, Gianfranco;Ogawa, Masahiro;Song, Juan;Chong, Voon J.;Joung, Boyoung;Han, Seongwook;Magri, Damiano;Chen, Lan S.;Lin, Shien-Fong;Chen, Peng-Sheng
通讯作者：
Chen, Peng-Sheng
DOI：
10.1152/ajpheart.00733.2004
发表时间：
2005-10-01
影响因子：
4.8
作者：
Saba, S;Janczewski, AM;London, B
通讯作者：
London, B
DOI：
10.1152/ajpheart.00431.2002
发表时间：
2003-02-01
影响因子：
4.8
作者：
London, B;Baker, LC;Salama, G
通讯作者：
Salama, G