These Are the Genes You're Looking For: Finding Host Resistance Genes.
These Are the Genes You're Looking For: Finding Host Resistance Genes.
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DOI：
10.1016/j.tim.2020.09.006
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发表时间：
2021-04
影响因子：
15.9
通讯作者：
Ko DC
中科院分区：
文献类型：
--
作者：
Bourgeois JS;Smith CM;Ko DC
Humanity’s ongoing struggle with new, reemerging, and endemic infectious diseases serves as a frequent reminder of the need to understand host-pathogen interactions. Recent advances in genomics have dramatically advanced our understanding of how genetics contributes to host resistance or susceptibility to bacterial infection. Here we discuss current trends in defining host-bacterial interactions at the genome-wide level, including screens that harness CRISPR/Cas9, natural genetic variation, proteomics, and transcriptomics. We report on the merits, limitations, and findings of these innovative screens and discuss their complementary nature. Finally, we speculate on future innovation as we continue to progress through the post-genomic era and towards deeper mechanistic insight and clinical applications.
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影响因子：
30.8
作者：
Ansari MA;Pedergnana V;L C Ip C;Magri A;Von Delft A;Bonsall D;Chaturvedi N;Bartha I;Smith D;Nicholson G;McVean G;Trebes A;Piazza P;Fellay J;Cooke G;Foster GR;STOP-HCV Consortium;Hudson E;McLauchlan J;Simmonds P;Bowden R;Klenerman P;Barnes E;Spencer CCA
通讯作者：
Spencer CCA
影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
3.7
作者：
Brown EL;Below JE;Fischer RS;Essigmann HT;Hu H;Huff C;Robinson DA;Petty LE;Aguilar D;Bell GI;Hanis CL
通讯作者：
Hanis CL
影响因子：
64.8
作者：
Chang, Howard C.;Paek, Jennifer;Kim, Dennis H.
通讯作者：
Kim, Dennis H.
影响因子：
16.6
作者：
Band, Gavin;Le, Quang Si;Kwiatkowski, Dominic P.
通讯作者：
Kwiatkowski, Dominic P.