Chemopreventive Effect of Aster glehni on Inflammation-Induced Colorectal Carcinogenesis in Mice.
Chemopreventive Effect of Aster glehni on Inflammation-Induced Colorectal Carcinogenesis in Mice.
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DOI：
10.3390/nu10020202
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发表时间：
2018-02-12
期刊：
影响因子：
5.9
通讯作者：
An HJ
中科院分区：
文献类型：
--
作者：
Chung KS;Cheon SY;Roh SS;Lee M;An HJ
摘要葛缕子是一种常见的草本植物，具有抗糖尿病、抗脂肪生成、抗炎等多种生物活性。还没有在结肠癌中研究过glehni。因此，我们假设了A. glehni（AG）对氧化偶氮甲烷/葡聚糖硫酸钠（AOM/DSS）诱导的小鼠结肠炎相关癌（CAC）的作用。在这项研究中，我们发现，AG治疗显着衰减AOM/DSS诱导的脾脏肿大和结肠缩短。此外，在AOM/DSS诱导的饲喂AG的小鼠中，结肠肿瘤形成、结肠损伤和肌肉厚度增加显著减少。AG治疗还减少了AOM/DSS诱导的CAC小鼠肠道白细胞介素（IL）-1β、IL-6和肿瘤坏死因子（TNF）-α的产生，并降低了诱导型一氧化氮合酶（iNOS）和环氧合酶（考克斯）-2蛋白的表达。AG还通过磷酸化和降解κ Bα抑制剂（IκBα）降低核因子（NF）-κB的活化，从而抑制NF-κB p65核转位。在AOM/DSS诱导的CAC小鼠中，它还下调NF-κ B相关蛋白的表达，包括B细胞淋巴瘤2（Bcl-2）家族和凋亡抑制蛋白（IAP）。总而言之，这些研究结果表明，AG治疗可抑制小鼠结肠炎相关的结肠癌发生，并且这种化学预防作用是通过抑制NF-κB信号通路强烈介导的，这表明AG可能是一种有前途的抗CAC保护剂。
Although Aster glehni is a common dietary herb that has various bioactivities, including anti-diabetic, anti-adipogenic, and anti-inflammatory effects, A. glehni has not been studied in colon cancer. Therefore, we hypothesized the chemopreventive effects of an ethanol extract of A. glehni (AG) on azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis-associated cancer (CAC) in mice. In this study, we found that treatment with AG significantly attenuated the AOM/DSS-induced enlargement of the spleen and shortening of the colon. In addition, colonic tumor formation, colonic damage, and increased muscle thickness were significantly reduced in AOM/DSS-induced mice fed AG. Treatment with AG also reduced intestinal interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α production and decreased inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein expression in mice with AOM/DSS-induced CAC. Furthermore, AG reduced nuclear factor (NF)-κB activation via phosphorylation and degradation of inhibitor of kappa Bα (IκBα), leading to inhibition of NF-κB p65 nuclear translocation. It also downregulated the expression of NF-κB-related proteins, including the B-cell lymphoma 2 (Bcl-2) family and inhibitors of apoptosis proteins (IAPs), in mice with AOM/DSS-induced CAC. Taken together, these findings suggest that the treatment with AG inhibited colitis-associated colon carcinogenesis in mice, and this chemopreventive effect was strongly mediated by suppression of the NF-κB signaling pathway, indicating that AG could be a promising protective agent against CAC.
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影响因子：
15.9
作者：
Gewirtz, AT;Rao, AS;Neish, AS
通讯作者：
Neish, AS
影响因子：
64.8
作者：
Tang, GL;Minemoto, Y;Lin, A
通讯作者：
Lin, A
Aster Glehni提取物的抗二磷酸作用：体内和体外作用。
DOI：
10.1155/2013/859624
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Lee HM;Yang G;Ahn TG;Kim MD;Nugroho A;Park HJ;Lee KT;Park W;An HJ
通讯作者：
An HJ
炎症和大肠癌：结肠炎相关的肿瘤。
影响因子：
9
作者：
Grivennikov, Sergei I.
通讯作者：
Grivennikov, Sergei I.
影响因子：
4.2
作者：
Davis, CD;Hord, NG
通讯作者：
Hord, NG