Antiadipogenic Effects of Aster glehni Extract: In Vivo and In Vitro Effects.
Antiadipogenic Effects of Aster glehni Extract: In Vivo and In Vitro Effects.
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Aster Glehni提取物的抗二磷酸作用：体内和体外作用。
DOI：
10.1155/2013/859624
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
An HJ
中科院分区：
文献类型：
--
作者：
Lee HM;Yang G;Ahn TG;Kim MD;Nugroho A;Park HJ;Lee KT;Park W;An HJ
紫菀是生长在郁陵岛的韩国传统草本植物。关于AG的几篇报道中没有一篇包括AG对脂肪形成影响的测定。本研究的主要目的是确定AG是否能减缓小鼠3T3-L1细胞和附睾脂肪组织的脂肪形成。AG以浓度依赖的方式阻断3T3-L1前脂肪细胞的分化，抑制脂肪形成相关基因如PPARγ、C/EBPα和SREBP1c的表达，这些基因是脂肪形成的主要调控因子。将雄性C57BL/6J小鼠随机平均分为4组：对照组（CON）、高脂饲粮（HFD）、高脂饲粮添加1% AG提取物（AG1）和高脂饲粮添加5% AG提取物（AG5）。实验动物分别饲喂HFD和2种组合，为期10周。与单独饲喂高脂饲料的小鼠相比，饲喂含AG高脂饲料的小鼠体重和内脏脂肪垫重量增加较少。此外，AG抑制了AG1和AG5处理小鼠附睾脂肪组织中PPARγ、C/EBPα、SREBP1c、LXR和瘦素等重要脂肪生成基因的表达。这些发现表明AG具有抗脂肪和抗肥胖作用，并提示其在肥胖和肥胖相关疾病中的治疗潜力。
Aster glehni (AG) is a Korean traditional herb that grows in Ulleungdo Island, Republic of Korea. None of the several reports on AG include a determination of the effect of AG on adipogenesis. The primary aim of this study was to determine whether AG attenuates adipogenesis in mouse 3T3-L1 cells and epididymal fat tissue. AG blocked the differentiation of 3T3-L1 preadipocytes in a concentration-dependent manner and suppressed the expression of adipogenesis-related genes such as PPARγ, C/EBPα, and SREBP1c, the master regulators of adipogenesis. Male C57BL/6J mice were divided randomly and equally into 4 diet groups: control diet (CON), high-fat diet (HFD), HFD with 1% AG extract added (AG1), and HFD with 5% AG extract added (AG5). The experimental animals were fed HFD and the 2 combinations for 10 weeks. Mice fed HFD with AG gained less body weight and visceral fat-pad weight than did the mice fed HFD alone. Moreover, AG inhibited the expression of important adipogenic genes such as PPARγ, C/EBPα, SREBP1c, LXR, and leptin in the epididymal adipose tissue of the mice treated with AG1 and AG5. These findings indicate antiadipogenic and antiobesity effects of AG and suggest its therapeutic potential in obesity and obesity-related diseases.
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影响因子：
10.5
作者：
Kim, JB;Spiegelman, BM
通讯作者：
Spiegelman, BM
DOI：
10.21273/jashs.133.4.492
发表时间：
2008-07-01
影响因子：
1.9
作者：
Harrison, Howard F., Jr.;Mitchell, Trevor R.;Snook, Maurice E.
通讯作者：
Snook, Maurice E.
影响因子：
5.4
作者：
Ono, Yuka;Hattori, Eri;Ohizumi, Yasushi
通讯作者：
Ohizumi, Yasushi
影响因子：
3.3
作者：
An, Hyo-Jin;Rim, Hong-Kun;Kim, Hyung-Min
通讯作者：
Kim, Hyung-Min
影响因子：
11.4
作者：
Schoonjans, K;PeinadoOnsurbe, J;Auwerx, J
通讯作者：
Auwerx, J