MicroRNA Involvement in Osteosarcoma.
MicroRNA Involvement in Osteosarcoma.
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作者：
Kobayashi E;Hornicek FJ;Duan Z
骨肉瘤（OS）是最常见的原发性恶性骨肿瘤，通常发生在青少年和年轻人的长骨。虽然近年来我们对OS的分子发病机制的认识有所增加，但我们仍然远未全面了解疾病的分子机制，如其肿瘤发生，疾病进展的特异性介质，化疗耐药性的发生和转移的发展。随着microRNA（miRNAs）的发现，其在分子生物学过程中的重要作用引起了包括肉瘤在内的肿瘤研究领域的极大兴趣。miRNAs是一类高度保守的非编码RNA，作为致癌基因或抑癌基因同时调控多个靶点发挥重要作用。最近使用miRNA表达谱的全基因组筛选已经鉴定了与癌症的生物学和临床特性相关的特定miRNA表达模式。此外，miRNAs及其靶基因或蛋白质可能是潜在的新型癌症生物标志物或治疗靶点。然而，为了将基于miRNA的治疗方法转化为临床环境，必须解决几个挑战。本文就miRNAs在OS中的作用进行综述，并重点介绍其作为生物标志物或治疗靶点的潜力。
Osteosarcoma (OS) is the most common primary malignant bone tumor, usually arising in the long bones of adolescents and young adults. While our knowledge of the molecular pathogenesis of OS has increased in recent years, we are still far from a comprehensive understanding of the molecular mechanisms of the disease, such as its tumorigenesis, specific mediators of disease progression, occurrence of chemoresistance, and development of metastasis. After the recent discovery of microRNAs (miRNAs), their critical roles in molecular biological processes have been of great interest in the cancer research field, including research on sarcomas. MiRNAs are highly conserved noncoding RNAs which play important roles as oncogenic or suppressive genes to simultaneously regulate multiple targets. Recent genome-wide screening using miRNA expression profiles has identified specific miRNA expression patterns that are associated with the biological and clinical properties of cancers. Additionally, miRNAs and their target genes or proteins can be potential novel biomarkers or therapeutic targets for cancer. However, there are several challenges that must be addressed in order to translate miRNA-based therapeutics to the clinical setting. In this review, we summarize the current understanding of the roles that miRNAs play in OS, and highlight their potential as biomarkers or therapeutic targets.
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影响因子：
2.8
作者：
Duan, Zhenfeng;Choy, Edwin;Hornicek, Francis J.
通讯作者：
Hornicek, Francis J.
DOI：
10.1016/j.bbrc.2009.07.101
发表时间：
2009-10-09
影响因子：
3.1
作者：
He, Chunlei;Xiong, Jianyi;Wang, Daping
通讯作者：
Wang, Daping
影响因子：
2.8
作者：
Kang, Hyun-Guy;Kim, Han-Soo;Han, Ilkyu
通讯作者：
Han, Ilkyu
影响因子：
4
作者：
Heneghan, Helen M.;Miller, Nicola;Kerin, Michael J.
通讯作者：
Kerin, Michael J.
影响因子：
6.4
作者：
Gougelet, Angelique;Pissaloux, Daniel;Alberti, Laurent
通讯作者：
Alberti, Laurent