The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm.
The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm.
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DOI：
10.1016/j.tins.2018.03.007
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发表时间：
2018-05
影响因子：
15.9
通讯作者：
Palmiter RD
中科院分区：
文献类型：
--
作者：
Palmiter RD
臂旁核(PBN)位于脑桥，被小脑的主要输出通路之一解剖，它将感觉信息(内脏不适、味道、温度、疼痛、瘙痒)传递到前脑结构，包括丘脑、下丘脑和杏仁核。在PBN神经元的亚群中选择性表达Cre重组酶的小鼠株的可用性，以及允许电路映射和操纵神经元功能的Cre依赖病毒的可用性，开始揭示PBN组成神经元的连接性和功能。本文综述了PBN神经元表达降钙素基因相关蛋白(CGRPPBN)的研究进展，CGRPPBN在调节食欲和向杏仁核传递真实或潜在威胁信号方面起着重要作用。文中还讨论了其他特定PBN神经元群的功能。这项审查旨在鼓励调查正在变得容易获得的许多悬而未决的问题。
The parabrachial nucleus (PBN), which is located in the pons and dissected by one of the major cerebellar output tracks, is known to relay sensory information (visceral malaise, taste, temperature, pain, itch) to forebrain structures including the thalamus, hypothalamus and extended amygdala. The availability of mouse lines expressing Cre-recombinase selectively in subsets of PBN neurons and of Cre-dependent viruses that allow circuit mapping and manipulation of neuron function is beginning to reveal the connectivity and functions of PBN’s component neurons. This review focuses on the PBN neurons that express calcitonin gene-related protein (CGRPPBN) that play a major role in regulating appetite and transmitting real or potential threat signals to the extended amygdala. The functions of other specific PBN neuronal populations are also discussed. This review aims to encourage investigation of the numerous unanswered questions that are becoming accessible.
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影响因子：
29
作者：
Denis RG;Joly-Amado A;Webber E;Langlet F;Schaeffer M;Padilla SL;Cansell C;Dehouck B;Castel J;Delbès AS;Martinez S;Lacombe A;Rouch C;Kassis N;Fehrentz JA;Martinez J;Verdié P;Hnasko TS;Palmiter RD;Krashes MJ;Güler AD;Magnan C;Luquet S
通讯作者：
Luquet S
影响因子：
15.9
作者：
Carleton A;Accolla R;Simon SA
通讯作者：
Simon SA
影响因子：
5.3
作者：
Alhadeff, Amber L.;Holland, Ruby A.;De Jonghe, Bart C.
通讯作者：
De Jonghe, Bart C.
影响因子：
5.3
作者：
Carter, Matthew E.;Han, Sung;Palmiter, Richard D.
通讯作者：
Palmiter, Richard D.
影响因子：
29
作者：
Campos CA;Bowen AJ;Schwartz MW;Palmiter RD
通讯作者：
Palmiter RD