Precision medicine in laryngeal cancer: protocol of the laryngeal cancer cohort (LARCH).
Precision medicine in laryngeal cancer: protocol of the laryngeal cancer cohort (LARCH).
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DOI：
10.1136/bmjopen-2022-067561
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发表时间：
2023-01-13
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
喉癌对社会经济弱势患者的影响不成比例。治疗可以使患者口服无效或需要永久气管切开术。在过去的30年里，存活率往好里说是静止不变，往坏里说是下降了。目前，还没有方法来预测患者对治疗的反应。喉癌队列(LARCH)旨在确定早期和晚期喉癌的手术和(化疗)放疗之间的生存率和生活质量结果的比较，以及喉癌的表现特征如何影响肿瘤学、功能和生活质量结果。这项研究是第一个增强喉癌疾病队列。在最初阶段，我们的目标是在3年内对8个中心的150名患者进行前瞻性队列研究。患者、肿瘤、生活质量和喉功能数据将在基线、6个月、12个月和24个月从喉鳞状细胞癌患者那里收集。多元Logistic回归分析将用于量化局部区域控制和确定与总体控制和按治疗方式相关的因素，并确定与总体和按治疗方式有关的生活质量的因素。大多数干预措施是作为常规护理的一部分进行的，落叶松提供了一种集中记录这些数据的机制。当在英格兰北部成功招聘时，我们计划在全国范围内推广落叶松；未来，落叶松可以作为该疾病的试验平台。研究结果将在影响较大的国际同行评议期刊上发表，并提交给科学会议。其他研究人员对匿名落叶松数据集的访问将得到宣传和推广。ISRCTN27819867。
Laryngeal cancer disproportionately affects socioeconomically disadvantaged patients. Treatment can render a patient nil by mouth or in need of a permanent tracheostomy. In the past 30 years, survival has remained at best static and at worst it has declined. Currently, there is no method of prognosticating how a patient will respond to treatment. The LARyngeal Cancer coHort (LARCH) aims to establish how survival and quality-of-life outcomes compare between surgery and (chemo)radiotherapy in early and advanced laryngeal cancer and how the presenting features of laryngeal cancer influence oncological, functional and quality-of-life outcome. This study is the first enhanced laryngeal cancer disease cohort. In the initial phase, we aim to deliver a prospective cohort study of 150 patients in 8 centres over a 3-year period. Patient, tumour, quality-of-life and laryngeal functional data will be collected from patients with squamous cell carcinoma of the larynx at baseline, 6, 12 and 24 months. Multiple logistic regression analyses will be used to quantify locoregional control and identify factors associated with control overall and by treatment modality and identify factors associated with quality of life overall and by treatment modality. Most interventions take place as part of routine care, with LARCH providing a mechanism for recording this data centrally. When successfully recruiting in the North of England, we plan to roll out LARCH nationwide; in the future, LARCH can be used as a trial platform in the disease. The results will be submitted for publication in high-impact international peer-reviewed journals and presented to scientific meetings. Access to the anonymised LARCH dataset by other researchers will be publicised and promoted. ISRCTN27819867.
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影响因子：
45.3
作者：
Urba, S;Wolf, G;Taylor, J
通讯作者：
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影响因子：
158.5
作者：
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WOLF, GT
DOI：
10.1002/hed.25630
发表时间：
2019-06-01
影响因子：
2.9
作者：
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通讯作者：
MacKenzie, Kenneth
影响因子：
158.5
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通讯作者：
Cooper, J
DOI：
10.1002/hed.24061
发表时间：
2016-04-01
影响因子：
2.9
作者：
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通讯作者：
Wilson, Janet A.