Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems.
Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems.
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DOI：
10.1038/s41467-023-43047-y
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发表时间：
2023-11-30
影响因子：
16.6
通讯作者：
Feasey, Nicholas
中科院分区：
文献类型：
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作者：
Barnes, Kayla G.;Levy, Joshua I.;Gauld, Jillian;Rigby, Jonathan;Kanjerwa, Oscar;Uzzell, Christopher B.;Chilupsya, Chisomo;Anscombe, Catherine;Tomkins-Tinch, Christopher;Mbeti, Omar;Cairns, Edward;Thole, Herbert;Mcsweeney, Shannon;Chibwana, Marah G.;Ashton, Philip M.;Jere, Khuzwayo C.;Meschke, John Scott;Diggle, Peter;Cornick, Jennifer;Chilima, Benjamin;Jambo, Kondwani;Andersen, Kristian G.;Kawalazira, Gift;Paterson, Steve;Nyirenda, Tonney S.;Feasey, Nicholas
COVID-19大流行对全球卫生系统产生了深远影响，强有力的监测对大流行控制至关重要，但目前并非所有国家都能维持社区病原体监测计划。废水监测已被证明在高收入环境中很有价值，但对低收入国家病原体水监测的效用知之甚少。在这里，我们展示了SAR-CoV-2的废水监测如何用于识别时间变化并帮助快速确定循环变体。在马拉维这个社区COVID-19检测能力有限的国家，我们探索利用河流和废水进行SARS-CoV-2监测。从2020年5月到2022年5月，我们从多达112条河流或废弃的污水处理厂收集水，在8.3%的样本中检测到SARS-CoV-2。水样中SARS-CoV-2的峰值检测早于临床病例中的峰值。对水样的测序鉴定了Beta、Delta和Omicron变体，Delta和Omicron在患者检测之前就已检测到。我们的工作重点是如何利用废水来检测新出现的波浪，识别令人担忧的变体，并在没有正式污水系统的环境中提供预警系统。COVID-19对卫生系统产生了不平等的影响，在全球范围内，用于社区监测的SARS-CoV-2检测受到了限制。马拉维的这项工作强调了如何利用河流和废水来检测新出现的SARS-CoV-2波，识别令人担忧的变种，并提供早期预警系统。
The COVID-19 pandemic has profoundly impacted health systems globally and robust surveillance has been critical for pandemic control, however not all countries can currently sustain community pathogen surveillance programs. Wastewater surveillance has proven valuable in high-income settings, but less is known about the utility of water surveillance of pathogens in low-income countries. Here we show how wastewater surveillance of SAR-CoV-2 can be used to identify temporal changes and help determine circulating variants quickly. In Malawi, a country with limited community-based COVID-19 testing capacity, we explore the utility of rivers and wastewater for SARS-CoV-2 surveillance. From May 2020–May 2022, we collect water from up to 112 river or defunct wastewater treatment plant sites, detecting SARS-CoV-2 in 8.3% of samples. Peak SARS-CoV-2 detection in water samples predate peaks in clinical cases. Sequencing of water samples identified the Beta, Delta, and Omicron variants, with Delta and Omicron detected well in advance of detection in patients. Our work highlights how wastewater can be used to detect emerging waves, identify variants of concern, and provide an early warning system in settings with no formal sewage systems. COVID-19 has impacted health systems unequally and widespread SARS-CoV-2 testing for community surveillance has been limited globally. This work in Malawi highlights how river and wastewater can be used to detect emerging SARS-CoV-2 waves, identify variants of concern, and provide an early warning system.
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影响因子：
6.4
作者：
Karthikeyan S;Nguyen A;McDonald D;Zong Y;Ronquillo N;Ren J;Zou J;Farmer S;Humphrey G;Henderson D;Javidi T;Messer K;Anderson C;Schooley R;Martin NK;Knight R
通讯作者：
Knight R
影响因子：
7.7
作者：
Augusto MR;Claro ICM;Siqueira AK;Sousa GS;Caldereiro CR;Duran AFA;de Miranda TB;Bomediano Camillo LM;Cabral AD;de Freitas Bueno R
通讯作者：
de Freitas Bueno R
DOI：
10.1371/journal.pgph.0001575
发表时间：
2023
期刊：
PLOS global public health
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.8
作者：
Haramoto, Eiji;Malla, Bikash;Kitajima, Masaaki
通讯作者：
Kitajima, Masaaki
影响因子：
5.8
作者：
Jackson, Ben
通讯作者：
Jackson, Ben