A unique Toxoplasma gondii haplotype accompanied the global expansion of cats.
A unique Toxoplasma gondii haplotype accompanied the global expansion of cats.
复制标题
DOI：
10.1038/s41467-022-33556-7
复制
发表时间：
2022-10-01
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
刚地弓形虫是一种包囊形成的顶复体寄生虫，几乎存在于所有的温血动物中，所有的猫科动物都是它的最终宿主。它是弓形虫病的病原体，弓形虫病是一种在世界范围内造成重大公共卫生负担的疾病。很少有洲际克隆谱系代表了全世界绝大多数的分离株。对于推动这些谱系成功的进化力量、它们全球传播的时间和机制，我们知之甚少。在这项研究中，我们分析了一组156个基因组，我们提供了T。弓形虫突变率和世代时间。阐明了T.弓形虫种群与猫的近代史上的重大事件密切相关。我们发现一个独特的单倍型，其长度仅占整个T。弓形虫基因组，是共同的所有洲际谱系和杂交人口来自这些谱系。这种单倍型伴随着野猫（Felis silvestris）从野外出现到国内定居点，它们在旧世界的传播，以及它们在过去五个世纪中向美洲的扩张。这种单倍型的选择是最简约的解释，其作用在有性生殖的T。家猫体内的弓形虫弓形虫可以感染所有的温血动物，猫科动物是最终宿主。尽管宿主范围广泛，但大多数临床和动物分离株属于少数克隆谱系。在这里，Galal等人对来自不同地理区域的分离株进行了全基因组测序，并估计了T。弓形虫突变率和世代时间。他们发现，最近的迁移浪潮将寄生虫从旧世界传播到新世界，并确定了一种独特的单倍型，这种单倍型可能伴随着猫的全球扩张，并且今天在所有洲际谱系和杂交种群中都很常见。
Toxoplasma gondii is a cyst-forming apicomplexan parasite of virtually all warm-blooded species, with all true cats (Felidae) as definitive hosts. It is the etiologic agent of toxoplasmosis, a disease causing substantial public health burden worldwide. Few intercontinental clonal lineages represent the large majority of isolates worldwide. Little is known about the evolutionary forces driving the success of these lineages, the timing and the mechanisms of their global dispersal. In this study, we analyse a set of 156 genomes and we provide estimates of T. gondii mutation rate and generation time. We elucidate how the evolution of T. gondii populations is intimately linked to the major events that have punctuated the recent history of cats. We show that a unique haplotype, whose length represents only 0.16% of the whole T. gondii genome, is common to all intercontinental lineages and hybrid populations derived from these lineages. This haplotype has accompanied wildcats (Felis silvestris) during their emergence from the wild to domestic settlements, their dispersal in the Old World, and their expansion in the last five centuries to the Americas. The selection of this haplotype is most parsimoniously explained by its role in sexual reproduction of T. gondii in domestic cats. Toxoplasma gondii can infect all warm-blooded animals, with felidae being the definitive hosts. Despite this broad host range, most clinical and animal isolates belong to few clonal lineages. Here, Galal et al. perform whole-genome sequencing of isolates from distinct geographical regions and estimate T. gondii mutation rate and generation time. They find that recent waves of migration disseminated the parasite from Old to New World and identify a unique haplotype that likely accompanied the global expansion of cats and is today common to all intercontinental lineages and hybrid populations.
登录
查看更多内容
DOI：
10.1093/bioinformatics/btx346
发表时间：
2017-10-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Gel B;Serra E
通讯作者：
Serra E
影响因子：
2.5
作者：
Innes, Elisabeth A.;Hamilton, Clare;Smith, David
通讯作者：
Smith, David
影响因子：
3.8
作者：
Hamidović A;Etougbétché JR;Tonouhewa ABN;Galal L;Dobigny G;Houémènou G;Da Zoclanclounon H;Amagbégnon R;Laleye A;Fievet N;Piry S;Berthier K;Pena HFJ;Dardé ML;Mercier A
通讯作者：
Mercier A
影响因子：
1.3
作者：
Basso, W;Venturini, L;Dubey, JP
通讯作者：
Dubey, JP
影响因子：
2.6
作者：
Gotteland, Cecile;Gilot-Fromont, Emmanuelle;Villena, Isabelle
通讯作者：
Villena, Isabelle