High NK cell activity in recurrent miscarriage: what are we really measuring?
High NK cell activity in recurrent miscarriage: what are we really measuring?
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复发性流产中 NK 细胞活性高：我们真正测量的是什么？
DOI：
10.1093/humrep/del131
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Ben-Eliyahu,Shamgar
中科院分区：
文献类型：
--
作者：
Shakhar,Keren;Rosenne,Ella;Loewenthal,Ron;Shakhar,Guy;Carp,Howard;Ben-Eliyahu,Shamgar
背景：一些研究表明，不明原因复发性流产（RM）的妇女外周血NK细胞的数量和活性增加，这些细胞水平的升高预示着RM妇女随后的流产。由于儿茶酚胺迅速动员NK细胞进入循环，这种增加可能不反映过度活跃免疫的稳定状态，而可能是由于与抽血相关的压力导致NK细胞数量的短暂增加。方法：22例对照组和38例RM患者在静脉插管后立即抽血，20分钟后再次抽血。测定淋巴细胞内NK细胞的百分比、每微升血液中NK细胞的浓度及其活性。结果：NK细胞的三项指标在两种样品的对照组中均无变化。然而，患有RM的女性在第一次血液样本中所有三种NK指数水平升高，但这些水平下降到与对照组相似的值。这种下降主要见于初次流产者，其NK活性在第一次抽血时最高。因此，在患有RM的女性中，下降的幅度与初始NK细胞指数之间存在高度相关。活性的变化与NK细胞浓度的变化高度相关。结论：先前在RM患者中观察到的NK数量和活性的增加可能是由于停血时的短暂应激反应。原发性RM患者在其他情况下可能表现为过度的急性应激反应。
BACKGROUND: Several studies have shown that women with unexplained recurrent miscarriage (RM) have increased numbers and activity of peripheral blood NK cells and that elevated levels of these cells predict subsequent miscarriages in women with RM. Because catecholamines rapidly mobilize NK cells into the circulation, such increases may not reflect a steady state of overactive immunity but may result from a transient increase in the number of NK cells because of the stress associated with blood withdrawal. METHODS: Blood was drawn from 22 controls and 38 RM patients immediately after vein cannulation, and again 20 min later. The percentage of NK cells within lymphocytes, their concentration per microlitre of blood and their activity were assessed. RESULTS: All three indices of NK cells did not change in the controls across the two samples. However, women with RM had elevated levels in all three NK indices in the first blood sample, but these levels declined to values similar to those seen in the controls. This decline was mainly observed in primary aborters whose NK activity was highest in the first blood withdrawal. Accordingly, there was a high correlation between the magnitude of the decline and the initial NK cell indices in women with RM. The change in activity highly correlated with the change in the concentration of NK cells. CONCLUSION: The increased NK number and activity previously observed in RM patients may result from a transient stress response at the time of blood withdrawal. Patients with primary RM may be characterized by exaggerated acute stress responses in other circumstances.
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DOI：
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