Development of cortical thickness and surface area in autism spectrum disorder.
Development of cortical thickness and surface area in autism spectrum disorder.
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DOI：
10.1016/j.nicl.2016.12.003
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发表时间：
2017
影响因子：
4.2
通讯作者：
Durston, Sarah
中科院分区：
文献类型：
--
作者：
Mensen, Vincent T.;Wierenga, Lara M.;van Dijk, Sarai;Rijks, Yvonne;Oranje, Bob;Mandl, Rene C. W.;Durston, Sarah
自闭症谱系障碍 (ASD) 是一种神经发育障碍，通常与皮质体积的变化有关。皮质体积的组成部分——皮质厚度和表面积——具有独立的发育轨迹，并且与不同的神经生物学过程相关。然而，人们对自闭症谱系障碍 (ASD) 皮质厚度和表面积的发育轨迹知之甚少。在这项磁共振成像 (MRI) 研究中，我们采用加速纵向设计来研究 90 名 ASD 患者和 90 名正常发育对照者的皮质发育情况，年龄为 9 至 20 岁。我们使用 FreeSurfer 软件包量化皮质测量值，然后使用线性混合模型分析来估计每个皮质测量值的发育轨迹。我们的主要发现是，自闭症谱系障碍 (ASD) 中表面积的发展遵循线性轨迹，这与典型的发展对照不同。在典型的发育过程中，我们发现 9 岁至 20 岁之间的皮质表面积有所下降，而自闭症谱系障碍 (ASD) 则不存在这种情况。我们在所有区域中发现了这种模式，这些区域的表面积发育轨迹在群体之间有所不同。当我们应用更严格的校正来考虑测量的相互依赖性时，这种对皮质表面积的影响对于颞上沟左岸、中央后区域和右侧边缘上区域仍然具有重要意义。这些区域以前曾与自闭症谱系障碍有关，并涉及视听社会刺激的解释和处理以及自我与他人的区分。尽管发现皮质体积和厚度存在一些差异，但没有经过更严格的多次测试校正。这项研究强调了区分皮质表面积和厚度在研究皮质发育中的重要性，并表明皮质表面积的发育对于自闭症谱系障碍非常重要。自闭症谱系障碍 (ASD) 的皮质发育与青春期的典型发育不同。这些主要是皮质表面积发育的差异。在大多数地区，对照组的表面积会减少，而自闭症谱系障碍患者的表面积不会减少。经过严格的多重测试修正后，这一模式在三个地区都成立。青春期皮质表面积的发育与 ASD 相关。
Autism spectrum disorder (ASD) is a neurodevelopmental disorder often associated with changes in cortical volume. The constituents of cortical volume – cortical thickness and surface area – have separable developmental trajectories and are related to different neurobiological processes. However, little is known about the developmental trajectories of cortical thickness and surface area in ASD. In this magnetic resonance imaging (MRI) study, we used an accelerated longitudinal design to investigate the cortical development in 90 individuals with ASD and 90 typically developing controls, aged 9 to 20 years. We quantified cortical measures using the FreeSurfer software package, and then used linear mixed model analyses to estimate the developmental trajectories for each cortical measure. Our primary finding was that the development of surface area follows a linear trajectory in ASD that differs from typically developing controls. In typical development, we found a decline in cortical surface area between the ages of 9 and 20 that was absent in ASD. We found this pattern in all regions where developmental trajectories for surface area differed between groups. When we applied a more stringent correction that takes the interdependency of measures into account, this effect on cortical surface area retained significance for left banks of superior temporal sulcus, postcentral area, and right supramarginal area. These areas have previously been implicated in ASD and are involved in the interpretation and processing of audiovisual social stimuli and distinction between self and others. Although some differences in cortical volume and thickness were found, none survived the more stringent correction for multiple testing. This study underscores the importance of distinguishing between cortical surface area and thickness in investigating cortical development, and suggests the development of cortical surface area is of importance to ASD. Cortical development differs between ASD and typical development in adolescence. These are primarily differences in the development of cortical surface area. In most regions surface area decreases for controls, not for individuals with ASD. After stringent multiple testing correction, this pattern held for three regions. The development of cortical surface area is relevant to ASD during adolescence.
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影响因子：
4.5
作者：
Hedman, Anna M.;van Haren, Neeltje E. M.;Pol, Hilleke E. Hulshoff
通讯作者：
Pol, Hilleke E. Hulshoff
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
5.7
作者：
Fischl, B;Salat, DH;Dale, AM
通讯作者：
Dale, AM
学龄前年份的大脑发育。
影响因子：
5.8
作者：
Brown, Timothy T.;Jernigan, Terry L.
通讯作者：
Jernigan, Terry L.