Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation.
Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation.
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DOI：
10.1016/j.micinf.2012.11.010
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发表时间：
2013-04
影响因子：
5.8
通讯作者：
Cramer RA
中科院分区：
文献类型：
--
作者：
Shepardson KM;Ngo LY;Aimanianda V;Latgé JP;Barker BM;Blosser SJ;Iwakura Y;Hohl TM;Cramer RA
Infection by the human fungal pathogen Aspergillus fumigatus induces hypoxic microenvironments within the lung that can alter the course of fungal pathogenesis. How hypoxic microenvironments shape the composition and immune activating potential of the fungal cell wall remains undefined. Herein we demonstrate that hypoxic conditions increase the hyphal cell wall thickness and alter its composition particularly by augmenting total and surface-exposed β-glucan content. In addition, hypoxia-induced cell wall alterations increase macrophage and neutrophil responsiveness and antifungal activity as judged by inflammatory cytokine production and ability to induce hyphal damage. We observe that these effects are largely dependent on the mammalian β-glucan receptor dectin-1. In a corticosteroid model of invasive pulmonary aspergillosis, A. fumigatus β-glucan exposure correlates with the presence of hypoxia in situ. Our data suggest that hypoxia-induced fungal cell wall changes influence the activation of innate effector cells at sites of hyphal tissue invasion, which has potential implications for therapeutic outcomes of invasive pulmonary aspergillosis.
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影响因子：
5.8
作者：
Chai, Louis Y. A.;Vonk, Alieke G.;Netea, Mihai G.
通讯作者：
Netea, Mihai G.
影响因子：
--
作者：
Gibbons, John G.;Beauvais, Anne;Rokas, Antonis
通讯作者：
Rokas, Antonis
影响因子：
20.3
作者：
Barber, Daniel L.;Mayer-Barber, Katrin D.;Sher, Alan
通讯作者：
Sher, Alan
影响因子：
4.4
作者：
Barker BM;Kroll K;Vödisch M;Mazurie A;Kniemeyer O;Cramer RA
通讯作者：
Cramer RA
影响因子：
2.2
作者：
Graham, Lisa M.;Tsoni, S. Vicky;Brown, Gordon D.
通讯作者：
Brown, Gordon D.